Anesthesia, General
Conditions
Brief summary
The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using SPI and EEG analysis.
Detailed description
Anesthetic agents vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there is no study that demonstrate the difference between analgesic potency of volatile anesthetics. The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using SPI and EEG analysis.
Interventions
DRUGSevoflurane
Anesthesia was maintained with sevoflurane in patients undergoing standardized nociceptive stimulus (long-lasting tetanic stimulus of the ulnar nerve; 30 s, 50 mA, 50 Hz, square-wave).
DRUGDesflurane
Anesthesia was maintained with desflurane in patients undergoing standardized nociceptive stimulus (long-lasting tetanic stimulus of the ulnar nerve; 30 s, 50 mA, 50 Hz, square-wave).
Sponsors
Kangbuk Samsung Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing general anesthesia using volatile anesthetics and supraglottic airway (I-gel™) * patients with american society of anesthesiologist physical status I, II * patients aged 19-65 years * patients obtaining written informed consent
Exclusion criteria
* patients with a history of any psychiatric or neurological disease * patients who had received any medication affecting the central nervous system * patients who had received medication affecting the sympathetic or parasympathetic nervous systems * patients undergoing tracheal intubation for airway management * pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Surgical pleth index | the 10 min at steady-state anesthesia after endotracheal intubation | The analgesic potency of volatile anesthetics was evaluated by surgical pleth index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bispectral index | the 10 min at steady-state anesthesia after endotracheal intubation | The hypnotic potency of volatile anesthetics was evaluated by bispectral index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation). |
Countries
South Korea
Outcome results
None listed