Obesity
Conditions
Keywords
chronic inflammation, fatty liver index
Brief summary
To evaluate the impact of obesity surgery on chronic inflammation.
Detailed description
A retrospective study to compare the impact of laparoscopic sleeve gastrectomy (LSG), laparoscopic Roux-en Y- gastric bypass (LRYGB) and laparoscopic omega-loop gastric bypass (LOLGB) on chronic inflammation and metabolic syndrome.
Interventions
Laboratory Examination before, 1 month, 3 month, 6 month and up to 12 month after LSK, LRNYGB, LOLGB
Sponsors
Sana Klinikum Offenbach
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* BMI \> 35kg/m² and obesity-related disease or BMI \> 40kg/m²
Exclusion criteria
* acute inflammation during laboratory examination
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Chronic inflammation | one day preoperatively, and 1 month, 3 month, 6 month and up to 12 month postoperatively | the changing of leucocytes in /nl after obesity surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Liver enzymes | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | the changing of GOT in U/l, GPT in U/l, GGT in U/l, AP in U/l after obesity surgery |
| Body Mass Index (BMI) in kg/m² | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | the changing of BMI in kg/m² before and after obesity surgery |
| weight in kg | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | the changing of weight before and after obesity surgery |
| waist circumference | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | the changing of waist circumference in cm before and after obesity surgery |
| Fatty liver index | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | the changing of fatty liver index after obesity surgery |
| Chronic inflammation II | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | the changing of c-reactive protein in mg/l after obesity surgery |
| Acute inflammation | one day preoperatively and one and four days postoperatively | the changing of c-reactive protein in mg/l after obesity surgery |
| Acute inflammation II | one day preoperatively and one and four days postoperatively | the changing of leucocytes in /nl after obesity surgery |
| HbA1c | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | the changing of HbA1c in % and after obesity surgery |
Outcome results
None listed