Local Intraoperative Analgesic Injection Versus Single Injection Interscalene Nerve Block in Patients Undergoing TSA

Local Intraoperative Analgesic Injection Versus Single Injection Interscalene Nerve Block in Patients Undergoing Shoulder Arthroplasty (TSA): A Randomized Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02695758

Enrollment

156

Registered

2016-03-01

Start date

2014-12-31

Completion date

Unknown

Last updated

2016-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis: Shoulder

Brief summary

A non-blinded randomized controlled trial, in which participants undergoing primary reverse or total shoulder arthroplasty are randomly assigned to one of two treatment groups.

Interventions

PROCEDUREInterscalene brachial plexus block

PROCEDUREbupivacaine extended-release liposome injection

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1\. All individuals undergoing primary reverse and total shoulder arthroplasty by the shoulder service at Methodist Hospital or Rothman Specialty Hospital.

Exclusion criteria

1. Psychiatric illness as defined by co-morbid diagnosis of bipolar disorder or schizophrenia 2. Revision arthroplasty, arthroplasty for fracture 3. Unable/unwilling to consent for enrollment 4. Unable to complete postoperative pain survey 5. Known adverse drug reaction or allergy to the medications used 6. Chronic pain syndromes (including reflex sympathetic dystrophy, fibromyalgia, chronic diffuse musculoskeletal pain) 7. Patients taking long acting narcotic pain medications (including extended release narcotic pain medications and methadone). 8. Patients under the age of 18 years 9. Patients with history of hepatic disease 10. Pregnant women or women who are breastfeeding

Design outcomes

Primary

Measure	Time frame
Morphine and Morphine Equivalent consumption	24 hours following surgery

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026