Varicocele
Conditions
Keywords
Doppler Ultrasound, Laparoscopic, Microscopic Subinguinal Varicocelectomy
Brief summary
To evaluate the benefits of laparoscopic Doppler ultrasound (LDU) assisted laparoscopic varicocelectomy (LV) and compare the surgical outcomes and complications between LDU assisted LV (LDU-LV) and microscopic subinguinal varicocelectomy for infertile patients with varicoceles.
Detailed description
To compare the surgical outcomes such as semen parameters and the pregnancy rate and complications like postoperative varicocele recurrence and hydrocele between laparoscopic Doppler ultrasound assisted laparoscopic varicocelectomy and conventional microscopic subinguinal for infertile patients with varicoceles. To examine the microanatomy of the spermatic cord within suprainguinal portion.
Interventions
PROCEDURELaparoscopic varicocelectomy
Traditional laparoscopic varicocelectomy assisted by laparoscopic Doppler ultrasound
PROCEDUREMicroscopic Subinguinal varicocelectomy
Infertile patients with clinically palpable varicoceles were selected to receive microscopic Subinguinal varicocelectomy
Sponsors
The Second Hospital of Shandong University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Investigator)
Eligibility
Sex/Gender
MALE
Age
20 Years to 39 Years
Healthy volunteers
No
Inclusion criteria
1. 20-39 years old who had infertility for more than 1 year and had clinical palpable varicoceles; 2. impaired semen quality including sperm concentration \<15 million/ml or total motility \<40% or progressively motile \< 32% (a+b), the 5th edited World Health Organization criteria was referred; 3. with normal level of serum hormones including follicle stimulating hormone, luteinizing hormone, Thyroid hormones and prolactin; 4. patient's spouse was healthy in reproduction.
Exclusion criteria
1. with subclinical varicocele, recurrent varicoceles; 2. normal semen analyses; 3. other reasons of infertility than varicoceles; 4. refusing to enter randomization; 5. female partner older than 35 years; 6. with abnormal level of serum hormones; 7. female factor infertility; 8. with significant surgical diseases, congenital diseases or endocrine diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy rate | The pregnancy rate was calculated at 1 year of follow-up |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| semen quality assessment | semen quality assessment were checked at 3, 6 and 12 months after surgery. | Routine sperm quality check including Count，Morphology and Motility using both the conventional manual method and computer assisted sperm analysis (CASA) systems. |
| postoperative complications | postoperative complications at 3, 6 and 12 months after surgery | — |
Countries
China
Contacts
Primary ContactShengtian Zhao, PHD
Outcome results
None listed