Impact of Time to Coronary Angiography on Survival for NSTEMI

Impact of Time to Coronary Angiography on Survival for NSTEMI: an Observation Study Using a Nationwide Registry

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02693015

Enrollment

235986

Registered

2016-02-26

Start date

2004-04-30

Completion date

2013-03-31

Last updated

2016-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non ST-elevation Myocardial Infarction

Brief summary

This study aims to investigate the extent to which the time to angiography impacts on survival in patients hospitalised with NSTEMI.

Detailed description

The use of an invasive strategy for the management of NSTEMI according to estimated risk of 6 month mortality is recommended by international guidelines. NSTEMI appropriate for coronary angiography (and percutaneous intervention) have better outcomes compare with NSTEMI who are medically managed. Whilst the national and international guidelines recommend that the timing of (in-hospital) coronary angiography (\<24, 24-72, 72-96 and \<96 hours) is based upon estimated clinical risk (using the GRACE risk score) there is scientific and clinical uncertainty as to the incremental benefit that more urgent invasive treatments strategies have over and above that of delayed strategies. Moreover, the investigators recent research has shown that in the UK, may NSTEMI (eligible) for coronary angiography fail to achieve care according to the recommended time thresholds, and this is associated with potentially avoidable premature death. This study aims to investigate the extent to which the time to angiography impacts on survival in patients hospitalised with NSTEMI. It will characterise patients according to their estimated risk of death, their time to angiography, and associated outcomes. The investigators anticipate that this observational study will provide Level B evidence for the benefits of the timing of an invasive strategy according to the GRACE risk score. The investigators are aware that the NICE guidelines for the management of acute chest pain are to be updated in 2016.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* The target population will be all patients aged 18 to 100 years recorded within MINAP from 2004 to 2013 who have been hospitalised with NSTEMI and received coronary angiography.

Exclusion criteria

* Age below 18 or above 100 or age missing * Diagnosis not NSTEMI * Patients who did not receive coronary angiography - as this is the investigators explanatory variable

Design outcomes

Primary

Measure	Time frame
All-cause mortality	30-day mortality since hospitalisation
Mortality	1-year mortality since hospitalisation

Outcome results