Inflammatory Mediators in Early Sepsis

Inflammatory Mediators in Sepsis as Indicator for Infection vs Inflammation

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02692118

Acronym

Tusep

Enrollment

Registered

2016-02-25

Start date

2016-12-31

Completion date

2022-09-30

Last updated

2021-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation

Brief summary

Sepsis is still a challenge for clinicians since the detailed pathomechanism are still unknown and until now early markers for sepsis are not defined yet. Immunological pathways and new mediators defined in animal models are not yet investigated in patients with sepsis. Therefore the investigators will measure new mediators in patients with septic shock.

Detailed description

Semaphorins 1 to 7 will be determined in Blood of patients with early septic shock. Concentration will be compared with blood concentration of postoperative patients suffering systemic inflammatory response syndrome (SIRS).

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Septic Shock

Exclusion criteria

* Age \< 18 \> 85 * no consent of caregiver * Trauma patients * Burn patients * Immunosuppression * Pregnancy * HIV- hepatitis infection

Design outcomes

Primary

Measure	Time frame	Description
Semaphorin 1 to 7 in plasma of septic patients	12 months	Concentration of Semaphorin in plasma of 60 sepsis patients \[pg/ml\].

Countries

Germany

Contacts

Primary ContactPeter Rosenberger, MD

peter.rosenberger@med.uni-tuebingen.de+49(0)7071298

Backup ContactHelene A Haeberle, MD

helene.haeberle@med.uni-tuebingen.de+49(0)7071298

Outcome results