Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception

Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception: A Randomized Controlled Trial

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02691858

Enrollment

Registered

2016-02-25

Start date

2015-04-30

Completion date

2025-12-31

Last updated

2024-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intussusception

Keywords

Intussusception

Brief summary

Intussusception is one of the most frequent causes of acute bowel and second most common cause of acute abdominal pain in pediatric age .95 % of cases are idiopathic, the rest are either due to pathological lead point or post operative. Treatment of intussusception must start with medical resuscitation, then radiological or operative reduction of intussusception. Our surgery team has used hydrocortisone with the medical resuscitation to improve the success rate of pneumatic reduction and decrease the number of reduction trials.

Detailed description

Experimental group will be given single dose IV Hydrocortisone 10 mg/kg with Resuscitation before attempting first trial of pneumatic reduction and the outcome measured. Control group will be given Saline 100 ml IV single injection with Resuscitation before attempting first trial of pneumatic reduction and the outcome measured.

Interventions

DRUGHydrocortisone

10 mg/kg with Resuscitation before attempting pneumatic reduction, single dose with Resuscitation before attempting reduction

DRUGSaline

100 ml with Resuscitation before attempting pneumatic reduction, single dose with Resuscitation before attempting reduction

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

3 Months to 4 Years

Healthy volunteers

Inclusion criteria

* Infantile Intussusception

Exclusion criteria

* Peritonitis Pneumoperitoneum Morbid patients

Design outcomes

Primary

Measure	Time frame	Description
Success of Pneumatic Reduction	1 Hour	Comparing number of Successful Pneumatic Reductions in both groups

Secondary

Measure	Time frame	Description
Reducing number of trials of Pneumatic Reduction	2 Hours	Comparing average number of Pneumatic Reduction trials between both groups
Reducing complications	2 Hours	Comparing number of complications in both groups

Countries

Egypt

Contacts

Primary ContactMostafa Gad, MSc

mostafagad@kasralainy.edu.eg201002265009

Backup ContactMahmoud Elfiky, MD

mfiky@kasralainy.edu.eg201001557755

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026