Point of Care Testing of Cholinesterase Activity During Burn- and Polytrauma

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02691650

Acronym

POCCET

Enrollment

Registered

2016-02-25

Start date

2016-02-29

Completion date

2018-10-31

Last updated

2019-04-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burns, Trauma

Keywords

serum cholinesterase, plasma cholinesterase, pseudocholinesterase, systemic inflammation, SIRS, polytrauma

Brief summary

Goal of this study is to measure serum cholinesterase activity in patients with traumatic and/or burns injury admitted to the emergency room by using point-of- care-test system (POCT). Serum cholinesterase activity, measured using POCT system, might play an important role in the early diagnosis and prediction of patient outcome in trauma-induced systemic inflammation.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* signed written consent * 18 years and older * severe trauma (ISS \> 15) * burns injury (2. degree more than 15% body surface or 3 degree more than 10% body surface) * SIRS

Exclusion criteria

* not fulfilling the inclusion criteria * failure to adhere

Design outcomes

Primary

Measure	Time frame	Description
Early diagnosis of the systemic inflammation by using the serum cholinesterase activity measurement	after completed patient recruitment, 1 year	By using Point-of-care measurement of serum cholinesterase activity (U/l) and by observing a change in the enzyme activity over time (reduction of serum cholinesterase activity within the first 6 hours after traumatic injury) would allow an additional tool in early diagnosis and treatment of systemic inflammation.

Secondary

Measure	Time frame	Description
correlation of the cholinesterase activity and the trauma/disease severity scores	after completed patient recruitment, 1 year	To evaluate the correlation of the serum cholinesterase activity change with the trauma severity, the obtained serum cholinesterase activities (U/l) will be compared to the trauma severity scores (ISS, %TBSA).

Countries

Germany

Outcome results