Screening for Chronic Kidney Disease (CKD) Among Older People Across Europe (SCOPE)

Conditions

Chronic Kidney Diseases

Keywords

Chronic Kidney Diseases, Older, Geriatric assessment, Biomarkers

Brief summary

The SCOPE study is an observational, multicenter, prospective cohort study aimed at evaluating a 2-year screening programme for CKD in a population of older patients, aged 75 years or more, in seven European Countries, in an attempt to investigate whether and to which extent currently available screening methods may identify older people at risk of worsening kidney function.

Ellen Freiberger, Paolo Fabbietti, Andrea Corsonello, Fabrizia Lattanzio, Cornel Sieber et al. (21 authors)

European Geriatric Medicine2024-02-286 citations

10.1007/s41999-024-00941-y

Transient versus stable nature of fear of falling over 24 months in community-older persons with falls- data of the EU SCOPE project on Kidney function.

Freiberger E, Fabbietti P, Corsonello A, Lattanzio F, Artzi-Medvedik R, Kob R, Melzer I, SCOPE consortium, Britting S.

2022-08-237 citations

10.1186/s12877-022-03357-0

Chronic kidney disease in the context of multimorbidity patterns: the role of physical performance : The screening for CKD among older people across Europe (SCOPE) study.

Corsonello A, Fabbietti P, Formiga F, Moreno-Gonzalez R, Tap L, Mattace-Raso F, Roller-Wirnsberger R, Wirnsberger G, Ärnlöv J, Carlsson AC, Weingart C, Freiberger E, Kostka T, Guligowska A, Gil P, Martinez SL, Melzer I, Yehoshua I, Lattanzio F, SCOPE investigators.

2020-10-0220 citations

10.1186/s12877-020-01696-4

Is kidney function associated with cognition and mood in late life? : The Screening for CKD among Older People across Europe (SCOPE) study.

Tap L, Corsonello A, Formiga F, Moreno-Gonzalez R, Ärnlöv J, Carlsson AC, Roller-Wirnsberger R, Wirnsberger G, Ziere G, Freiberger E, Sieber C, Kostka T, Guligowska A, Gil P, Martinez SL, Artzi-Medvedik R, Yehoshua I, Fabbietti P, Lattanzio F, Mattace-Raso F, SCOPE investigators.

2020-10-027 citations

10.1186/s12877-020-01707-4

Kidney function and other factors and their association with falls : The screening for CKD among older people across Europe (SCOPE) study.

Britting S, Artzi-Medvedik R, Fabbietti P, Tap L, Mattace-Raso F, Corsonello A, Lattanzio F, Ärnlöv J, Carlsson AC, Roller-Wirnsberger R, Wirnsberger G, Kostka T, Guligowska A, Formiga F, Moreno-Gonzalez R, Gil P, Martinez SL, Kob R, Melzer I, Freiberger E, SCOPE investigators.

2020-10-026 citations

10.1186/s12877-020-01698-2

Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study: a multicenter cohort observational study.

Corsonello A, Tap L, Roller-Wirnsberger R, Wirnsberger G, Zoccali C, Kostka T, Guligowska A, Mattace-Raso F, Gil P, Fuentes LG, Meltzer I, Yehoshua I, Formiga-Perez F, Moreno-González R, Weingart C, Freiberger E, Ärnlöv J, Carlsson AC, Bustacchini S, Lattanzio F, SCOPE investigators.

2018-10-1124 citations

10.1186/s12882-018-1030-2

Interventions

OTHERblood sample collection

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

75 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* age≥75 years * subjects attending the outpatient services at participating institutions

Exclusion criteria

* ESRD or dialysis * history of solid organ or bone marrow transplantation * active malignancy within 24 months prior to screening or metastatic cancer * life expectancy less than 6 months * severe cognitive impairment (MMSE\<10), * any medical or other reason that the subject is unsuitable for the study * subjects unwilling to provide consent

Design outcomes

Primary

Measure	Time frame	Description
Rate of estimated Glomerular Filtration Rate (eGFR) decline	24 months	eGFR will be calculated using the Berlin Initiative Study 1 (BIS1) equation
Incidence of End Stage Renal Disease (ESRD)	24 months	ESRD will be defined as eGFR\<15 mL/min/1.73 m2 or dialysis

Secondary

Measure	Time frame	Description
Incidence of CKD complications	24 months	anemia, hyperphosphatemia, acidosis, hypoalbuminemia, hyperparathyroidism, hyperkaliemia
Incidence of major comorbidities	24 months	myocardial infarction, hospitalization for unstable angina, transient ischemic attack/stroke, heart failure events, interventional cardiology events, peripheral vascular intervention, and stent thrombosis
Biomarkers of kidney function	Baseline and 24 months	cystatin C, beta2-microglobulin, beta-trace protein
Comprehensive geriatric assessment (CGA)	Baseline and 24 months	Cognitive function (Mini Mental State Examination), depression (Geriatric Depression Scale), functional assessment (Basic Activity of Daily Living, Lawton Instrumental Activities of Daily Living Scale), health status (Cumulative Illness Rating Scale for Geriatrics), risk of malnutrition (Mini Nutritional Assessment), dietary intake assessment (24-h Dietary Recall), history of falls and incident falls, vision and hearing impairment, socioeconomic Status, physical Performance (Short Physical Performance Battery Test), muscle strength (Hand Grip Strength), quality of life (Euro-Qol 5D)
Healthcare resource consumption	Baseline and 24 months	previous physician visits, use of care services, hospital admissions, laboratory tests performed
Cardiovascular mortality	24 months	death resulting from acute myocardial infarction, sudden cardiac death, heart failure, stroke, CV procedures, CV hemorrhage, and other CV causes
Genetic and epigenetic analyses	Baseline and 24 months	circulating microRNA, telomere length in circulating leukocytes, DNA methylation, analysis of the whole genome

Countries

Austria, Germany, Israel, Italy, Netherlands, Poland, Spain

Outcome results

None listed