Depressive Disorder, Treatment-Resistant
Conditions
Keywords
Treatment Resistant Depression
Brief summary
The purpose of this study is to assess the epidemiology of Treatment Resistant Depression (TRD) in the nationally insured population in Taiwan including incidence, duration of clinical episodes, and prevalence by age and sex.
Detailed description
This is a retrospective study of approximately one million subjects randomly selected from an anonymized database National Health Insurance Research Database (NHIRD). Participants aged 18 years or older who have had neither a depression diagnosis nor a dispensing of an antidepressant medication in the last four months of 2004 will enter the study when they receive in 2005 a depression diagnosis and a dispensing of an antidepressant medication within 30 days of each other and will be followed up to 8 years or until they have 4 months with neither a depression diagnosis nor a dispensing of an antidepressant medication. Treatment Resistant Depression (TRD) Incidence, TRD prevalence by age and sex and duration of clinical episodes will be estimated.
Interventions
None listed
Sponsors
Elysia Group
Janssen Research & Development, LLC
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participants who have been continuously enrolled in the insurance plan since January 1, 2004 (ignoring breaks of less than 30 days) and have not received an exclusion diagnosis and during the last 4 months of 2004, a) Have not received a diagnosis of depression and b) Have not received a dispensing of an AD medication * Participants with a diagnosis of a depressive disorder including dysthymic disorder (International Classification of Diseases \[ICD\]-9 codes 296 depression-related, 300.4, 311) and Major Depressive Disorder (ICD-9 296.2, 296.3) will be followed through December 31, 2013
Exclusion criteria
\- Participants who receive following diagnosis will be excluded, a) Mania, b) Schizophrenia (ICD-9 codes 295), c) Bipolar disorder (ICD-9 codes 296 bipolar-related), D) Dementia (ICD-9 codes 290 or 294); Note: Major depressive disorder (MDD) with psychotic behavior (ICD 296.24 for single episode, ICD 296.34 for recurrent episode) is not an exclusion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence Percentage of Participants with Treatment Resistant Depression | Approximately 8 Years | The percentage of beneficiaries of Taiwan's health insurance plan who developed treatment resistant depression during 2005 |
| Prevalence Percentage of Participants with Treatment Resistant Depression | Approximately 8 Years | — |
| Duration of an episode of Depression | Approximately 8 Years | Time from onset of depression to cessation of depression visits and medications. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Healthcare costs | Approximately 8 Years | Direct healthcare cost associated with depression treatment will be assessed. |
| Number of Participants With Comorbidities | Approximately 8 Years | — |
| Medications used by Participants with Treatment Resistant Depression | Approximately 8 Years | — |
Outcome results
None listed