Block
Conditions
Keywords
pregabalin, spinal anesthesia
Brief summary
Pregabalin, an anticonvulsant is widely used for treatment of neuropathic pain. Recently, it was reported that premedication of pregabalin before general anesthesia is effective to reduce postoperative pain. Up to date, there is no study about the effect of premedication of pregabalin on the spinal anesthesia. Therefore, in this study, investigators investigate the effect of premedication of pregabalin on the spinal anesthesia.
Detailed description
In this study, investigators investigate the effect of premedication of pregabaline 150 mg on the spinal anesthesia. Two hours before spinal anesthesia, placebo pill was administered to patients in the group C and pregabalin 150 mg was administered to patients in the group P, respectively. Time for the onset of blockade, cephalad level of analgesia and duration of analgesia were measured.
Interventions
DRUGPlacebo
DRUGPregabalin
Sponsors
Kyungpook National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patients of American Society of Anaesthesiologists Grades I and II
Exclusion criteria
* Patients with infection at the puncture site, coagulopathy, having true hypersensitivity to drugs used, diabetes and hypertension, psychiatric and neurological diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of spinal anesthesia | 24 hours after spinal anesthesia | Duration of spinal anesthesia was measured 24 after spinal anesthesia |
Countries
South Korea
Outcome results
None listed