Perioperative Endothelial Dysfunction in Patients Undergoing Minor Abdominal Surgery

Perioperative Endothelial Dysfunction in Patients Undergoing Minor Abdominal Surgery. The POETRY Minor Study.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02690233

Acronym

POETRYminor

Enrollment

Registered

2016-02-24

Start date

2016-02-29

Completion date

2017-06-30

Last updated

2018-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Injury

Keywords

endothelial dysfunction, surgery, cardiovascular complications, EndoPat, myocardial injury, myocardial infarction

Brief summary

This study on minor surgery serves to explore whether a dose-response relationship exists between surgical stress and endothelial dysfunction in the early postoperative period. The aim of this explorative and observational clinical study is to closely examine the endothelial function and its dynamics in the early postoperative period after minor surgery (lap. inguinal hernia repair). The endothelial function will be assessed indirectly by EndoPat and plasma biomarkers of nitric oxide bioavailability. The study will contribute to the understanding of perioperative myocardial injury, which is crucial for optimized treatment of patients at risk of cardiovascular complications.

Detailed description

The investigators will include 60 patients undergoing elective inguinal hernia repair. The endothelial function will be measured before surgery and 4 hours after surgery with the EndoPat system. The NO-bioavailibility will be measured by plasma l-arginine, plasma ADMA and plasma biopterins.

Interventions

PROCEDUREElective Surgery

Elective laparoscopic inguinal hernia repair

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients scheduled for a laparoscopic inguinal hernia repair * Patients ≥ 18 years old

Exclusion criteria

* Not capable of giving informed consent after oral and written information * Previously included in the trial - Surgery within 7 days of the trial

Design outcomes

Primary

Measure	Time frame
Change in endothelial function assessed by the EndoPat system	At baseline and 4 hours postoperatively

Secondary

Measure	Time frame
Change in biomarkers of endothelial function: plasma arginine, plasma ADMA, plasma biopterins	At baseline and 4 hours postoperatively

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 22, 2026