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Three Different Oral Hygiene Regimes on Three Volatile Sulfur Compounds

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02689297
Enrollment
30
Registered
2016-02-23
Start date
2013-09-30
Completion date
2013-11-30
Last updated
2016-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Halitosis

Brief summary

The purpose of the study is to evaluate the effect of various oral hygiene regimes on three volatile sulfur compounds.

Detailed description

Thirty male monk volunteers who matched with the including criteria were divided randomly into two groups. Both groups were practiced to brush their teeth with scrubbing method for one week. Then, each group were instructed to do different additional protocol regimen- group A have to do mouth washing and tooth brushing and group B have to practice tongue cleaning addition to tooth brushing for three weeks. At the fifth week, both groups were instructed to practice tooth brushing, mouth washing and tongue cleaning. Three different volatile sulfur compounds were measured by oral chroma. Tongue characteristics, oral examination were checked as the outcomes of this study.

Interventions

First week, subjects were instructed to do regular tooth brushing. After that group A was requested to use chlorine dioxide mouthwash two time per days for three weeks in addition to tooth brushing and then, one week for combination of tooth brushing, tongue cleaning and mouth washing.

OTHERsmall toothbrush for tongue cleaning

First week, subjects were instructed to do regular tooth brushing. After that group B was requested to brush their tongue with small toothbrush two time per days for three weeks in addition to tooth brushing and then, one week for combination of tooth brushing, tongue cleaning and mouth washing.

Sponsors

Tokyo Medical and Dental University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)

Eligibility

Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes

Inclusion criteria

* Clinical diagnosis of oral malodor * No systemic diseases and no severe dental diseases * At least 20 functional teeth

Exclusion criteria

* Risky oral habit (smoking and betel quid chewing) * Current use of antibiotics or any drugs * Current use of any kind of mouthwash

Design outcomes

Primary

MeasureTime frameDescription
Three different volatile sulfur compoundsup to 5weeksInvestigator measured three different volatile sulfur compounds: hydrogen sulfide, methyl mercaptan, dimethyl sulfide concentrations (ng/10ml) by using Oral chroma.

Secondary

MeasureTime frameDescription
Oral Health examinationup to 5weeksAs oral examination, investigator examined present teeth, DMF-T (decayed, missing and filled teeth)
Tongue coating characteristicsup to 5weeksAs tongue coating characteristics, investigator examined tongue coating score (by using winkle tongue coating index) at the baseline, one week later, four weeks later and five weeks later.
Number of teeth with bleeding on probingup to 5weeks
Plaque index scoreup to 5weeks

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026