Non Variceal Bleed
Conditions
Brief summary
All patients with non variceal bleed who are admitted under the Department of Hepatology at Institute of Liver and Biliary Sciences, who meet the inclusion criteria and who provide informed consent.
Interventions
BIOLOGICALFresh Frozen Plasma
BIOLOGICALPlatelets Concentrate
BIOLOGICALCryo Precitipitate
Sponsors
Institute of Liver and Biliary Sciences, India
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age more than 18 * All patient with Non Variceal bleed (INR\>1.8 and platelets\<50000) * Hist logical or imaging proven liver cirrhosis.
Exclusion criteria
1. Variceal Bleed, 2. Pregnancy., 3. Patients on anticoagulation 4. Patients who refused to participate in the study 5. Post EVL ulcer bleed
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of FFP (Fresh Frozen Plasma) transfusion in both groups | 42 days |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients with bleed in both groups | 5 days |
| Incidence of TRALI (Transfusion associated lung injury) and TACO ( Transfusion associated circulatory overload) in both the groups. | 42 days |
| Early mortality ( <6 weeks) and late mortality (> 6 weeks) in both the groups. | 42 days |
| Amount of blood products (Platelet and cryo and Red Blood Cells)transfused in both the groups. | 42 days |
Countries
India
Outcome results
None listed