Type 2 Diabetes
Conditions
Brief summary
This observational study is conducted to determine how the duodenal layer thicknesses (mucosa, submucosa, and muscularis) vary with several factors in patients with and without type 2 diabetes.
Detailed description
Study Objectives 1. To assess duodenal layer (mucosa, submucosa and muscularis) thickness differences between patients with and without type 2 diabetes using endoscopic ultrasound (EUS) and optical coherence tomography (OCT). 2. To assess duodenal layer thickness differences between patients with type 2 diabetes. 3. To assess duodenal layer thickness differences as a function of measurement location along the length of the duodenum. 4. To compare measurements obtained by endoscopic ultrasound, to those obtained by optical coherence tomography.
Interventions
PROCEDUREEUS and OCT imaging
Intraluminal imaging using endoscopic ultrasound and endoscopic optical coherence tomography
Sponsors
Victoria Gomez
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patient is already scheduled for upper endoscopy with ultrasound or OCT, such as those with Barrett's esophagus. * Patient is willing to sign an informed consent form.
Exclusion criteria
* Patient is not a candidate for endoscopy, EUS, or OCT, such as those with strictures, inflammatory disease or previous anastomosis of the esophagus or duodenum.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thickness of the duodenal mucosa using OCT, and EUS if possible | During imaging |
Secondary
| Measure | Time frame |
|---|---|
| Thickness of the duodenal submucosa using OCT if possible, and EUS | During imaging |
Other
| Measure | Time frame |
|---|---|
| Thickness of the duodenal muscularis using OCT if possible, and EUS | During imaging |
Countries
United States
Outcome results
None listed