Muscle Damage
Conditions
Keywords
strenuous exercise, muscle soreness
Brief summary
The primary purpose of this interventional, placebo controlled, crossover, double blind, basic science exploratory study is to investigate whether there is a difference in brain electrophysiological oscillatory activity in healthy adults before and after oral consumption of water containing very small bubbles of oxygen (electrokinetically modified water).
Interventions
DIETARY_SUPPLEMENTControl Unmodified Placebo Water
DIETARY_SUPPLEMENTElectrokinetically modified water (EMW)
Sponsors
NYU Langone Health
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Men or women of any ethnic background; * living in New York tri-state area; * fluent in English; * normal or corrected to normal vision and hearing; * willing to complete all study procedures; and * capable of giving written informed consent.
Exclusion criteria
* A history of gross brain abnormalities such as stroke, severe ventriculomegaly or severe periventricular white matter abnormalities; * a history of serious psychiatric or neurological disorders, including psychosis or major depression, alcohol or drug abuse, brain injury, seizure disorder, brain tumor, etc.; * taking psychoactive medications, including antipsychotics, anxiolytics and antidepressants, or cognitive enhancers such as cholinesterase inhibitors; * presence of contraindications for MEG or MRI recording, including any of the following: cardiac pacemaker, intracranial clips, metal implants, or external clips within 10 mm of the head, metal in eyes, claustrophobia, obesity and/or any other reason leading to difficulty staying in the MEG or MRI for up to one hour.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in spectral properties measured before and after drinking the test products using Magnetoencephalography (MEG) measurements | 1 Week | Magnetic fields will be recorded using a 275-channel whole-head MEG system |
| Changes in localization of spontaneous brain activity measured before and after drinking the test products using Magnetoencephalography (MEG) measurements | 1 Week | Magnetic fields will be recorded using a 275-channel whole-head MEG system |
Secondary
| Measure | Time frame |
|---|---|
| Self reported changes in behavioral state before and after drinking test product | 1 Week |
Countries
United States
Outcome results
None listed