The Effect on Glycemic Responses and Subjective Ratings of Satiety of a Snack With or Without Ingredients to Slow Carbohydrate Digestion

Randomized, Controlled, Cross-over Study Comparing The Effect on Glycemic Responses and Subjective Ratings of Satiety of a Snack With or Without Ingredients to Slow Carbohydrate Digestion

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02688283

Enrollment

Registered

2016-02-23

Start date

2015-11-30

Completion date

2016-04-30

Last updated

2018-09-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glycemic Response; Satiety

Brief summary

The objective of this trial is to compare a snack with ingredients (whole grains and dietary fiber) to slow carbohydrate digestion to a similar control snack without such ingredients and evaluate the effect of the snack on glycemic response and subjective satiety. The test product will be compared with a control product as well as white bread in a randomized, controlled, crossover trial including 20 healthy males or females between the ages of 18 and 70 and having a body mass index (BMI) between 25 and 30 kg/m2. Following an overnight fast, participants will be given each of the study products in a random order at least a week apart. Glucose and insulin will be measured before product consumption and over a period of four hours. Visual analog scales to measure subjective satiety will also be administered over a period of four hours.

Interventions

OTHERNutrient cluster

Test cluster is an optimized savory cluster made through a proprietary baking process combined with slow digestible carbohydrates and fiber

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

1. Healthy males or females between the ages of 18 and 70 inclusive 2. No chronic medications other than oral contraceptives 3. Body Mass Index (BMI) between 25 and 30 kg/m2 inclusive. 4. Body weight stable in a 5 kg range in the 3 months prior to study entry

Exclusion criteria

1. Pregnant or nursing a baby 2. Women with child-bearing potential who are unwilling to use an effective means of contraception during the study which could include abstinence. 3. Adults unable to consent and prisoners

Design outcomes

Primary

Measure	Time frame
area under the curve (AUC) for glucose and insulin	0-4 hours post consumption

Secondary

Measure	Time frame
AUC for the visual analog scale (VAS) ratings of satiety	0-4 hours post consumption

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026