Multiple Sclerosis
Conditions
Keywords
Multiple Sclerosis, Upper limb rehabilitation
Brief summary
An adequate upper limb function is crucial to independently perform Activities of Daily Living (ADL). Persons with neurological diseases often experience upper limb dysfunction. Upper limb function in Multiple Sclerosis (MS) is highly prevalent, increasing with overall disability level, while the detrimental impact on ADL is higher than in stroke, given that symptoms often occur bilaterally. In contrast to stroke, it is unknown whether similar rehabilitation principles and effect sizes apply in MS given that this progressive neurodegenerative disease is characterized by multiple lesions and atrophy of brain structures. To date, optimal therapy dosage of upper limb rehabilitation programs are not known in the MS literature neither were characteristics of responders identified. The aim of this explorative study is to investigate the intensity dependent clinical effects of a task-oriented upper limb training in persons with MS with different upper limb disability levels.
Interventions
OTHERTask-oriented upper limb training
Participants in the experimental groups (high-intensity and low-intensity) receive for 8 weeks, 60 min/day, 5 days/week a task-oriented upper limb rehabilitation training at a high or low intensity, respectively, instead of their regular occupational therapy hours provided in the conventional multidisciplinary rehabilitation program. The task-oriented training involves practicing of functional daily tasks, with the intention to acquire or reacquire a skill. Most functional upper limb tasks require following essential movement components: reaching, moving, positioning, transporting, lifting the upper limb and/or an object and grasping, releasing, stabilizing, manipulating an object. The Tagtrainer of SymbioTherapy is used to support the independent training of tasks with real objects with different sizes and weights. The Diego of Tyromotion is used in patients who require assistance (gravity support) during the performance of different upper limb tasks.
OTHERControl intervention
The participants in the control group receive for 8 weeks the conventional multidisciplinary rehabilitation program (physiotherapy, occupational therapy and speech or cognitive therapy if needed). The training sessions are scheduled for 60 min/day, 5 days/week for the duration of 8 weeks.
Sponsors
Hasselt University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years * Diagnosis of MS (McDonald criteria) * Progressive type of MS (primary or secondary progressive MS) * A score 1 or more on the performance scale: item hand function
Exclusion criteria
* A relapse or relapse-related treatment within the last 3 months prior to the study * Complete paralysis of both upper limbs * Marked or severe intention tremor (Fahn's tremor rating scale \> 3) * Other medical conditions interfering with the upper limb function (ortopaedic or rheumatoid impairment) * Severe cognitive or visual deficits interfering with testing and training
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Training tolerance | daily through study compeletion | Questionnaire of training tolerance and possible adverse effects |
| pinch grip strength | 8 weeks | pinch grip strength |
| Nine Hole peg test | 8 weeks | Manual dexterity |
| Manual Ability Measure-36 | 8 weeks | Questionnaire about perceived ADL performance |
| Isometric hand grip | 8 weeks | Isometric hand grip |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Box and block test | 8 weeks | Manual dexterity |
| Action Research Arm Test | 8 weeks | Proximal and distal upper limb function |
| Motricity Index | 8 weeks | General isometric muscle strength |
| Virtual Peg Insertion Test | 8 weeks | manual dexterity |
| Accelerometers (Actigraph) | 8 weeks | actual upper limb performance in daily life |
| Test d'Évaluation des Membres Supérieurs des Personnes Âgées (TEMPA) | 8 weeks | Proximal and distal upper limb function |
| Muscle fatigue indices | 8 weeks | Indices calculated based on a 30 seconds sustained maximal isometric hand grip contraction |
| Tactile sensitivity in the fingers Semmens-Weinstein monofilaments | 8 weeks | Tactile sensitivity in the thumb and index |
| Rydel Seiffer Tuning fork | 8 weeks | Vibration in the upper limb |
| Symbol digit modalities test | 8 weeks | Cognitive function, processing speed |
Countries
Belgium
Outcome results
None listed