Postpartum Haemorrage Sever Bleeding After Delivery
Conditions
Keywords
obstetric bleeding placenta previa
Brief summary
This study evaluate role of tranexamic acid in reducing blood loss among pregnant women undergoing cesarean section because of placenta previa .Half of participants will receive tranexamia acid drug While the other half will receive placebo.
Detailed description
Tranexamic Acid used in the field of obstetrics to decrease blood loss during and after cesarean section . Tranexamic Acid is an antifibrinolytic agent which cause reversible and competitive blockade of the lysine binding sites in plasminogen molecules . It is a synthetic analog of amino acid lysine and its action is to reduce blood loss
Interventions
DRUGTranexamic Acid
tranexamic acid or placebo are given before cesarean section in patient with placenta previa
Sponsors
Medical Research Council
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 38 Years
Healthy volunteers
No
Inclusion criteria
* age 18 -38 Body mass index \<30 , Diagnosis of placenta previa
Exclusion criteria
* patient with bleeding disorder , hepatic and renal disease. contraindication to tranexamic acid as allergy , hypersensitivity to tranexamic acid and known thromboembolic event during pregnancy . other causes ofantepartum haemorrhage eg :accidental haemorrhage, rupture uterus. type 1,2 of placenta previa anterior type 3,4 of placenta previa posterior causes of overdistended uterus like :multiple pregnancy, polyhydraminos
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amount of Actual blood loss in each group | 6hour after operation | observational |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference in haemoglobin before operation and 24 hours after operation | 24 hours | observational |
Outcome results
None listed