Perioperative Myocardial Injury
Conditions
Keywords
Copeptin, human
Brief summary
Observational cohort study examining the perioperative course of copeptin in patients undergoing elevated-risk surgery.
Interventions
None listed
Sponsors
Heinrich-Heine University, Duesseldorf
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults \>18 years * Type of surgery for patients 1 to 30: abdominal aortic aneurysm repair, suprainguinal and infrainguinal vascular surgery, carotid surgery * Type of surgery for patients 31 to 500: surgeries with elevated risks in general (as specified by 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management \[Kristensen\])
Exclusion criteria
* acute coronary Syndrome (ACS) at presentation (clinical assessment or documentation) * Congestive heart failure at presentation (clinical assessment or documentation) * Documented severe aortic stenosis (valve area \<1cm2) * Kidney dysfunction (clearance \<50ml/min) * Reduced left ventricular ejection fraction (LVEF) (\<40%); if no LVEF is available, it will be assumed to be \>40% * Cancelled surgery * Unwilling or unable to provide consent * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| perioperative copeptin concentrations | perioperative from induction of anesthesia to the third postoperative day | copeptin concentrations for the perioperative time course as measured by the ThermoFisher assay at induction, at 0h, 2h, 4h, 6h, 8h, as well as on the postoperative day 1 and 3. |
| composite events composed of all-cause mortality and/or major adverse cardiac and cerebrovascular events (MACCE) | 12 months | MACCE defined as:non-fatal cardiac arrest, acute coronary syndrome (including MINS), congestive heart failure requiring hospitalization or transfer to a higher unit of care, and stroke |
| myocardial injury in non-cardiac surgery (MINS) | 3 postoperative days | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| all-cause mortality | 12 months | — |
| composite events composed of all-cause mortality and/or major adverse cardiac and cerebrovascular events (MACCE) | 30 days | MACCE: non-fatal cardiac arrest, acute coronary syndrome (including MINS), congestive heart failure requiring hospitalization or transfer to a higher unit of care, and stroke |
Countries
Germany, Switzerland
Outcome results
None listed