Pre-procedure Planning for Radiofrequency Ablation Using CT or MR/US Fusion

Pre-procedure Planning for Radiofrequency Ablation Using the Automatic Fusion Images of the Registrated 3D CT or MR-US Scans: Preliminary Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02687113

Enrollment

240

Registered

2016-02-22

Start date

2013-03-31

Completion date

2015-03-31

Last updated

2016-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Cancer

Keywords

ablation, fusion

Brief summary

The purpose of this study is to determine whether fusion technique of pre-radiofrequency ablation (RFA) cross-sectional imaging (CT or MR) and real-time ultrasonography would improve feasibility of RFA in patients with liver tumor in comparison with ultrasonography guidance alone.

Detailed description

RFA is one of commonly used local therapies for primary or secondary liver tumors. For successful and safe procedure, safe route of electrode and lesion visibility are essential for RFA, and the conditions are usually evaluated on pre-RFA planning ultrasonography (USG). However, RFA is sometimes aborted due to limited sonic window of various cause and challenging identification of small isoechoic tumors or hepatocellular carcinomas among dysplastic nodules . Therefore, precise targeting and assuring safe route would be of clinical importance. In this preliminary study, investigators attempted to determine US and CT/MR fusion technique would be able to improve RFA feasibility in patients with liver tumors in comparison with conventional US alone technique.

Interventions

DEVICECT/US fusion

Fusion of pre-RFA cross-sectional imaging (CT or MRI) and real-time USG using registration function of USG device.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

all conditions should be satisfied for inclusion. * referred to Radiology in our institution for liver tumor RFA * available pre-RFA liver CT or liver MR imaging within 6 weeks

Exclusion criteria

patients with any of following condition should be excluded. * any contraindication of liver RFA * any patients who received treatment between pre-RFA imaging and planned RFA * patients referred for palliative purpose.

Design outcomes

Primary

Measure	Time frame	Description
RFA feasibility rates on planning USG with/without fusion CT/MR and US	10 minutes after finishing planning USG	comparison of rates of RFA feasibility on conventional planning USG and on fusion planning USG

Secondary

Measure	Time frame	Description
Rate of tumor visibility on planning USG with/without fusion technique	10 minutes after finishing planning USG	comparison of tumor visibility (or detection) rates on planning USG on conventional planning USG and fusion planning USG
Number of patients with safety access route on planning USG with/without fusion technique	10 minutes after finishing planning USG	comparison of number of patients with presence/absence of safety access route, and the on two planning USGs

Other

Measure	Time frame	Description
Anticipated number of overlapping of RFA electrodes on planning USG with/without fusion technique	30 minutes after finishing planning USG	comparison of anticipated number of electrode overlapping on two planning USGs

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 12, 2026