Infertility
Conditions
Brief summary
Assisted Reproductive Technologies (ARTs) are widely used in couples with fertility problems. However, despite ART treatment options have evolved over time, the implantation rate remains rather low. A possible role for inherited and acquired thrombophilias has been invoked, especially in women with previous implantation failures. However, several factors could play a role in these conditions. A potential benefit of low-molecular-weight heparin (LMWH) in improving ART outcomes, independently of the presence of thrombophilia, has been recently suggested. This register is designed in order to better define all possible variables influencing ART outcome and improve clinical management of women with previous implantation failures. During this study the investigators will collect and evaluate clinical data regarding the first cycle in women with previous ART failures.
Interventions
None listed
Sponsors
Casa Sollievo della Sofferenza IRCCS
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* 2 or more implantation failures/losses of clinical pregnancies after ART * ART cycle at enrolment * Informed consent
Exclusion criteria
* Ovarian hypofunction * Uterine pathology * Hydrosalpinges * Previous inclusion in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of live births | 10 months |
Secondary
| Measure | Time frame |
|---|---|
| Number of clinical pregnancies after ART | 10 months |
Countries
Italy
Contacts
Primary ContactElvira Grandone
Backup ContactMichela Villani
Outcome results
None listed