Endometriosis, Ovarian Reserve
Conditions
Keywords
endometrioma, laparoscopy, anti-mullerian hormone, ovarian reserve
Brief summary
Laparoscopic excision of endometriotic cysts is the main stream surgical intervention for treatment of endometriosis. However there is evidence that intervention may effect ovarian reserve by destruction of healthy ovarian tissue during surgery. Available evidence on the topic are contradictory and employed research methodology are diverse. There is need for an adequately powered research with proper methodology to assess actual effects of surgery.
Interventions
PROCEDURELaparoscopic removal of cysts
Women with endometrioma lesions will undergo laparoscopic removal. Cysts will be enucleated with blunt dissection of the cyst capsule and following traction, counter traction maneuver. Bipolar coagulation will be used sparsely and suturing will be the predominant choice for achieving bleeding control.
Sponsors
Ankara University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Women with endometrioma cyst(s) * Women of age under 35 years old * Women without any previous ovarian surgery
Exclusion criteria
* Combined oral contraceptive or long term GnRH (gonadotropin-releasing hormone) analog use in the preceding 3 months to enrolment * Having another cystic lesion besides endometrioma * Need for extensive bipolar coagulation during surgery * Any anatomical problem preventing evaluation of ovaries with high-resolution ultrasound * Postoperative pathology excluding endometrioma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Anti-Mullerian hormone levels | 1 year | AMH (anti-mullerian hormone) levels will be measured before surgery and during various time points up to 1 year after the surgery |
Contacts
Primary ContactErkan Kalafat
Outcome results
None listed