Cystic Fibrosis
Conditions
Brief summary
Patients with cystic fibrosis older than 18 years will performance a Bruce test with non invasive ventilation (once) after 30 minutes they perform the same test with oxygen supplementation. Measurements: Transcutaneous level off carbon dioxide, saturation, puls and dyspnea scale.
Detailed description
measurements before and after the test: transcutaneous level off carbon dioxide, saturation, respiratory rate, dyspnea scale.
Interventions
DEVICENon invasive ventilation
Training on treadmill with Non invasive ventilation
DEVICEOxygen
Training on treadmill with oxygen
Sponsors
Karolinska University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Subjects with Cystic Fibrosis at Stockholm Cystic Fibrosis center * \> 18 years of age * Forced expiratory volume in one second (FEV1) between 20 and 69% of predicted value * Developed alveolar hypoventilation at the physical performance test * Use oxygen supplementation during aerobic training
Exclusion criteria
* Symptomatic upper airway infection characterized by fever less than 1 month before entering the study * Cognitive dysfunction * Cardio-respiratory instability * Infection with Burkholderia cepacia complex * Gastroesophageal reflux * History of pneumothorax * Massive hemoptysis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Transcutaneous level carbon dioxide | 10 min measurement | Physiological parameter |
Countries
Sweden
Outcome results
None listed