Liver Disease
Conditions
Brief summary
To examine the quality of liver images produced when the contrast agent Eovist is used during MRI.
Detailed description
Researchers will review data from the Eovist MRI and compare the scan with previous MRI exams the patient had with the same or other contrast agents. To determine the efficacy of Eovist contrast agent in producing MRI images of the liver. We will monitor patients for any unusual symptoms (adverse events) when the contrast is given. Patients are asked to hold their breath during an MRI scan. Eovist may interfere with the breath hold which could result in more breathing artifacts (based on a qualitative scale) on arterial images when the patients are given Eovist vs. other contrast agents.
Interventions
PROCEDUREEovist Contrast
Subjects will undergo an MRI (magnetic resonance imaging) scan using the Eovist contrast agent. This MRI scan takes approximately 45minutes to 1 hour to complete.
PROCEDURENon Eovist Contrast
Subjects will undergo an MRI (magnetic resonance imaging) scan using a contrast agent other than Eovist. This MRI scan takes approximately 45minutes to 1 hour to complete.
Sponsors
University of Michigan
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. You have had a scheduled MRI(magnetic resonance imaging) scan using the contrast agent EOVIST. 2. Male and females 21 years of age or older.
Exclusion criteria
1. Does not have a contraindication for MRI (e.g. cardiac pacemaker, ferromagnetic or metallic implants). 2. Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Scanning artifacts on MRI with Eovist | 5 years | To qualitatively assess and score MRI images during unenhanced and contrast-enhanced motion-sensitive sequences for breathing artifacts when Eovist contrast is used versus other contrast agents. Eovist enhanced MRI scans will be compared to previous MRI scans performed with other contrast agents on the same patient that included breath holding sequences. Breathing artifacts on both scans will be evaluated using a respiratory motion score between 1 and 5. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Adverse events (including dyspnea) | 30 min | Number of patients complaining of adverse events after MRI contrast administration. |
Countries
United States
Outcome results
None listed