Diabetes Mellitus, Type 2, Heart Disease
Conditions
Brief summary
The study will be performed as a cross-sectional survey. 300 Type 2 diabetes patients (T2DM), with or without known cardiovascular disease, will be recruited from the diabetes outpatient clinic, Slagelse Hospital. The patients will undergo echocardiography, Cardiac magnetic resonance imaging (CMR), clinical examination and will be asked to fill out questionnaires. This study project sets out to answer the following hypotheses: 1. Patients with T2DM have an increased risk of developing diastolic dysfunction. Using CMR, the investigators wish to measure left ventricle peak filling rate and passive atrial emptying fraction as a measure of cardiac diastolic function. The investigators hypothesize that classic T2DM markers such as levels of urinary albumin excretion, retinopathy, autonomic neuropathy, hypertension, dyslipidemia, elevated HgbA1c, T2DM duration, etc. are associated with pathological findings by CMR. 2. Patients with T2DM have impaired left ventricle myocardial perfusion as determined by gadolinium contrast CMR. The investigators hypothesize that the classic markers and risk factors mentioned above, are associated with left ventricle myocardial hypoperfusion as determined by gadolinium contrast CMR.
Interventions
An extensive explorative CMR protocol, including time/volume curves of LV and LA, rest and stress perfusion (with Adenosin) and time/volume curve of LA after chronotropic stress with Glycopyrrolate, further flow measurements and T1 mapping.
OTHEREchocardiography
Standard measurements and strain.
OTHERBood samples
HbA1c, Glucose, Hgb, Creatinin, Sodium, Potassium, Total cholesterol, LDL cholesterol, HDL cholesterol, Free fatty acids, ALAT, Urinary albumin, NT-proBNP, ANP, suPAR, Copeptin, Proendothelin, proCNP, Soluble ST2, Galectin-3
Sponsors
Slagelse Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Male or female patient fully capable of informed consent * Informed consent * T2DM * Age 18-80 (both years included)
Exclusion criteria
* Contraindications to CMR (pacemakers/ICD-units, cochlear implants) * Lack of consent * Atrial fibrillation * eGFR \< 30 ml/min/1,73m2 (only
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| On CMR; left ventricle peak filling rate (ml/s) | Cross-sectional so at baseline | Measure for cardiac diastolic function; including measurements at rest and after glycopyrrolate chronotropic stress |
| On CMR, LV myocardial perfusion | Cross-sectional so at baseline | Including measurements at rest and with Adenosin stress |
| On CMR; passive atrial emptying fraction (%) as a measure for cardiac diastolic function | Cross-sectional so at baseline | Measure for cardiac diastolic function; including measurements at rest and after glycopyrrolate chronotropic stress |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Echocardiography | Cross-sectional so at baseline | Systolic function |
| Blod samples | Cross-sectional so at baseline | NT-proBNP, ANP, suPAR, Copeptin, Proendothelin, proCNP, Soluble ST2, Galectin-3 |
Countries
Denmark
Outcome results
None listed