Infant Development, Infant Overnutrition
Conditions
Brief summary
The purpose of this study is to measure energy expenditure during the first 3 months of life in infants.
Detailed description
This study intends to establish the feasibility of undertaking comprehensive metabolic phenotyping in infants. The overarching aim is to complete a prospective assessment of energy expenditure in the new infant metabolic chamber approximately one week apart to determine the accuracy and precision of infant protocols related to energy metabolism (sleeping metabolic rate, resting metabolic rate, diet-induced thermogenesis) and physical activity. This cross-sectional study will answer the following questions: 1. What is the test re-test reliability of measuring energy expenditure (sleeping metabolic rate, resting metabolic rate, diet-induced thermogenesis) in an infant under the same conditions, 5-7 days apart? 2. What is the reliability of 24h energy expenditure estimated by the infant metabolic chamber in comparison to a 7-day doubly labeled water study? 3. How do energy expenditure measurements in infants need to be adjusted to account for variability in infant size and body composition?
Interventions
None listed
Sponsors
Pennington Biomedical Research Center
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
1 Months to 3 Months
Healthy volunteers
Yes
Inclusion criteria
* Healthy, full-term infant * Aged 1 month (28 days) to 3 months (12 weeks, 6 days) at the first visit * Exclusively fed breast milk and/or infant formula * Willing to accept doubly-labeled water
Exclusion criteria
* Unable to complete 3 clinic visits within about 14 days at Pennington Biomedical Research Center * Born preterm (\< 37 weeks gestation) * Congenital abnormality or disability * Gastric reflux * Acute illness within 7 days of the study (fever, diarrhea) * Use of medications to treat a chronic condition (does not include use of vitamin supplements or PRN medication for flatulence or reflux such as Pepcid)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy Expenditure by infant metabolic chamber | Approximately 1 week | Energy expenditure by infant metabolic chamber measured twice about 1 week apart for test re-test reliability in infants aged 1-3 months. |
| Energy expenditure by doubly labeled water | Approximately 1 week | Energy expenditure by doubly labeled water measured over approximately 7 days in infants aged 1-3 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percent body fat | Approximately 1 week | Percent body fat by PEA POD measured twice about 1 week apart for test re-test reliability in infants aged 1-3 months. |
| Physical activity counts | Approximately 1 week | Physical activity counts by Actigraph accelerometer measured over approximately 7 days in infants aged 1-3 months. |
Countries
United States
Contacts
CONTACTAbby Altazan, M.S.
PRINCIPAL_INVESTIGATORLeanne M Redman, Ph.D.
Pennington Biomedical Research Center
Outcome results
None listed