Compartment Syndrome, Osteonecrosis, Pseudarthrosis
Conditions
Keywords
Magnetic resonance imaging, perfusion, quantitative
Brief summary
Study on quantitative perfusion parameters acquired on MR imaging of patients with non-tumoral pathology of the musculoskeletal system.
Detailed description
Patients referred for the MR imaging evaluation of non-tumoral musculoskeletal pathology (osteonecrosis, pseudarthrosis and compartment syndrome) will have their MR protocols complemented by a contrast enhanced perfusion study. In this patients standard clinical evaluation is already performed with contrast medium injection (Gadolinium) and no additional injection is required. After post processing multiple quantitative perfusions parameters will be extracted (e.g. plasmatic volume, transfer constant, backflow constant, extra-cellular extra vascular space volume). The variation of these parameters in patients with and without the previously described conditions will be compared.
Interventions
OTHERT1 mapping and MR perfusion acquisition
One T1 mapping acquisition with variable flip angles will be performed before contrast injection. One perfusion 3D FSPGR sequence will be acquired after contrast injection
Sponsors
University Hospital, Lille
Central Hospital, Nancy, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* affiliation to a social security regimen * Signature of an informed consent * Clinical suspicion of one of the studied conditions (osteonecrosis of the wrist, osteonecrosis of the femoral head, pseudarthrosis and compartment syndrome)
Exclusion criteria
* MR contraindications * Contraindications to contrast injection * Previous history of allergy to gadolinium containing contrast medium * Presence of metallic hardware in the study zone * Pregnancy * Patients under tutelage
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Variation of the plasmatic volume estimation in the 5 study groups (arms) and between the images acquired in the two inclusion sites. | 3 years | The plasmatic volume (Vp%) in ml is a quantitative perfusion parameter that describes the capillar density of the tissues evaluated and can be useful in tissue characterization |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Variation of the plasma-extra-cellular space transfer constant in the 5 study groups (arms) and between the images acquired in the two inclusion sites. | 3 years | The plasma-extracellular space transfer constant (Ktrans) in min -1 is a quantitative perfusion parameter that is related to the capillar permeability and blood flow. This parameter can be useful for tissue characterization. |
| Variation of the extra-cellular space-plasma transfer constant (backflow constant) in the 5 study groups (arms) and between the images acquired in the two inclusion sites. | 3 years | The extracellular-space-plasma transfer constant or backflow constant (Kep) in min -1 is a quantitative perfusion parameter that is related to the capillar permeability. This parameter can be useful for tissue characterization. |
| Variation of the extra-cellular extra-vascular space volume in the 5 study groups (arms) and between the images acquired in the two inclusion sites. | First 6 months of inclusion | The extracellular-space extra-vascular space volume (Ve%) in ml is a quantitative perfusion parameter that is related to the tissue cellularity. This parameter can be useful for tissue characterization. |
Countries
France
Contacts
Primary ContactPedro TEIXEIRA, MD, PhD
Backup ContactGabriela Hossu, PhD
Outcome results
None listed