Effect of Ca2+ Ionophore on Embryonic Development and Clinical Outcome in Cases With Previous Fertilization Arrest

A Prospective Randomized Controlled Trial Investigating Embryonic Development and Clinical Outcome After Using Ca2+ Ionophore in Cases With Previous Fertilization Arrest

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02683031

Enrollment

Registered

2016-02-17

Start date

2014-05-31

Completion date

2017-12-31

Last updated

2016-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertilization Arrest

Keywords

fertilization arrest, Cleavage failure, Embryonic development, Calcium ionophore

Brief summary

We aimed to investigate the efficiency of chemical oocyte activation using readymade Ca2+ ionophore on cases with previously cancelled cases due to fertilization arrest at pronuclear stage i.e: cleavage failure to find out if there is any improvement in embryonic developmental stages.

Detailed description

Many studies reported that Ca2+ ionophore has a positive effect on embryo development in cases with complete or partial fertilization failure. However, only one preliminary report suggested a beneficial effect of Ca2+ ionophore activation in four cases with fertilization arrest.

Interventions

OTHERCa2+ ionophore

Ca2+ ionophore is a chemical agent used to perform oocyte activation after ICSI. It showed effective treatment to get better fertilization, pregnancy, and healthy livebirth in cases with total or partial fertilization failure.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 39 Years

Healthy volunteers

Inclusion criteria

* Patients with previous history of complete fertilization arrest. * ovarian stimulation with the GnRH agonist and recombinant FSH in a long protocol.

Exclusion criteria

* Female age \>40 years

Design outcomes

Primary

Measure	Time frame	Description
Blastocyst formation rate	5 to 7days post oocyte retrival	Defined as the total number of blastocyst / total number of cleaved Embryos

Countries

Egypt

Contacts

Primary ContactYasmin Magdi, M.Sc

Yas.magdi@hotmail.com+201282313979

Backup ContactAhmed El-Damen, M.Sc

Ahmed_eldamen@Yahoo.com+201002414342

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026