Trait Anxiety and Defensive Networks

Trait Anxiety Modulates Resting State Functional Connectivity of Defensive Networks

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02682888

Enrollment

131

Registered

2016-02-17

Start date

2015-12-08

Completion date

2021-11-20

Last updated

2022-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

brain functional connectivity changes

Brief summary

to examine the association between trait and defensive network connectivity and the modulatory effect of oxytocin on it

Detailed description

Individuals with high trait anxiety show stable anxiety proneness even in the absence of real threat, which could be a result of intrinsic hyper-connectivity in the defensive systems. In the present study, healthy subjects' trait anxiety levels will be assessed by the sub-trait inventory of the State-Trait Anxiety Inventory. Then two experiments using resting-state fMRI technique will be conducted to first map how hubs in the defensive systems organized in high anxious individuals in a stimuli-free situation (Experiment 1) and then we will examine the modulatory effect of the intranasal administration of oxytocin on functional connectivity in these independently defined defensive networks (Experiment 2).

Interventions

BEHAVIORALtrait anxiety scale

splitting subjects into 2 groups according to scores of the trait anxiety scale

DRUGOxytocin

intranasal administration of oxytocin

DRUGPlacebo

intranasal administration of placebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

* females should not be pregnant or during menstruation.

Design outcomes

Primary

Measure	Time frame	Description
the resting state functional connectivity changes in the defensive network	one day	The resting-state activity can be accessed using functional magnetic resonance imaging (fMRI) by measuring spontaneous and low-frequency fluctuations (\< 0.1 Hz) when the brain is at rest. Group differences will be calculated in the high trait anxiety group relative to the low trait anxiety group and in the oxytocin group relative to the placebo group.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026