Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02682706

Acronym

MIBAT

Enrollment

Registered

2016-02-15

Start date

2016-02-29

Completion date

2018-03-31

Last updated

2018-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

brown adipose tissue, magnetic resonance imaging, energy expenditure, non-shivering thermogenesis

Brief summary

Brown adipose tissue (BAT) is unique in its capability to convert chemical energy directly into heat. Active BAT increases energy expenditure and can thereby counteract obesity and insulin resistance. Currently, the imaging method of choice to assess BAT morphology and function is 18F-FDG-PET/CT which is expensive and exposes patients or healthy volunteers to ionizing radiation, thus impeding larger prospective studies. Magnetic resonance imaging (MRI) could constitute a suitable alternative and preliminary small-scale studies are promising. The overall aim of this research proposal is to develop reliable magnetic resonance imaging techniques to facilitate the study of brown adipose tissue in human adults, specifically in the context of endocrine disease. Specifically, investigators want to 1. Develop a reliable MR imaging protocol for human BAT and compare BAT volume to cold induced nonshivering thermogenesis as a measure of BAT activity. 2. Assess the intra-individual variance of BAT volume measured by MRI. 3. Evaluate direct measurement of BAT temperature by functional MRI.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers * Age 18-40 years * Body mass index (BMI): 17.5-27 kg/m²

Exclusion criteria

* known concomitant disease influencing thyroid hormone metabolism * severe diseases: chronic heart failure, liver cirrhosis, kidney failure, active cancer * known hypersensitivity to cold, e.g. primary or secondary Raynaud's syndrome * abuse of alcohol or illicit drugs * Women who are pregnant or breast feeding * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant * Previous enrolment into the current study * implanted device not compatible with MRI, e.g. pace maker

Design outcomes

Primary

Measure	Time frame	Description
Correlation of scBAT volume and cold induced thermogenesis as determined by indirect calorimetry	both measurements within 2 weeks	measurement of scBAT volume and measurement of cold induced thermogenesis as determined by indirect calorimetry, both values measured in a timeframe of two weeks

Countries

Switzerland

Outcome results