Alzheimer Disease, Major Depressive Disorders, Schizophrenia
Conditions
Keywords
Genome-wide association studies, Environmental factors, Behavioral Assessment, Pathway analysis
Brief summary
To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.
Detailed description
The investigators plan to collect behavioral assessment and environmental factors data,peripheral blood sample, MRI brain images in more than 10,000 healthy young Chinese Han individuals in order to build the pathway from gene to high-level cognitive phenotypes.
Interventions
None listed
Sponsors
Tianjin Medical University Cancer Institute and Hospital
Tianjin Medical University Second Hospital
Tianjin First Central Hospital
Pingjin Hospital,Logistics University of Chinese People's Armed Police Forces
School of Medical Imaging, Tianjin Medical University
Tianjin Huanhu Hospital
Beijing Hospital
Chinese PLA General Hospital
Beijing Tongren Hospital
Xuanwu Hospital, Beijing
Peking Union Medical College Hospital
Beijing Normal University
Chinese Academy of Sciences
The Second Hospital of Hebei Medical University
The First Affiliated Hospital of Shanxi Medical University
Inner Mongolia Medical College Hospital
The First Hospital of Jilin University
The Frist Hospital Of China Medical University
The First Affiliated Hospital of Dalian Medical University
RenJi Hospital
Huashan Hospital
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Nanjing PLA General Hospital
The First Affiliated Hospital with Nanjing Medical University
Xuzhou Medical University
Second Affiliated Hospital, School of Medicine, Zhejiang University
First Affiliated Hospital of Wenzhou Medical University
The First Affiliated Hospital of Anhui Medical University
Shan dong Medical Imaging Research Institute
Qilu Hospital of Shandong University
Yantai Yuhuangding Hospital
Henan Provincial People's Hospital
The First Affiliated Hospital of Zhengzhou University
Tongji Hospital
Wuhan University
Xiangya Hospital of Central South University
Central South University
Guangdong Provincial People's Hospital
The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
South China Normal University
First Affiliated Hospital Xi'an Jiaotong University
Xijing Hospital
Tang-Du Hospital
LanZhou University
West China Hospital
Second Affiliated Hospital of Wenzhou Medical University
University of Electronic Science and Technology of China
First Affiliated Hospital of Chongqing Medical University
Southwest Hospital, China
The University of Science and Technology of China
Guangdong No.2 Provincial People's Hospital
Tianjin Medical University General Hospital
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* aged 18-30 * Chinese Han * right-handed * without history of neuropsychiatric disease * no substance addiction * smoking
Exclusion criteria
* younger or elder than 18-30 year-old * other ethnics * with history of neuropsychiatric disease * with history of neuropsychiatric disease among first,second and third degree relatives
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain structure and function measured by MRI scans | 2 years | The participants will receive non-interventional multi-modal MRI scans, such as 3D-T1WI, DTI, DKI, ASL, REST-fmri, then the investigators can acquire the brain volume in region of interest, such as bilateral hippocampus. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Childhood adversities as assessed by Childhood Trauma Questionnaire-Short Form (Chinese Version) | 2 years | To investigate impact of the adversities in early life of participants on brain structure and function as well as the interaction effect of childhood adversities and genetic variations,such as 5-HTTLPR polymorphism. |
Countries
China
Contacts
Primary ContactChunshui Yu, PhD
Backup ContactQiang Xu, PhD
Outcome results
None listed