Recurrent Implantation Failure (RIF)
Conditions
Keywords
Recurrent implantation failure, Freeze all policy, endometrial receptivity, implantation, clinical outcome
Brief summary
This is the first study to investigate, whether pregnancy and implantation rates would improve in patients with recurrent implantation failure (RIF), if all embryos were to be frozen and transferred in a consecutive natural cycle.
Detailed description
There is growing evidence that elective frozen-thawed embryo transfer in a non-stimulated cycle (freeze-all policy) would eliminate the risk of controlled ovarian stimulation and resulting in better endometrial receptivity and lower uterine contractility as compared with fresh intracytoplasmic sperm injection (ICSI) cycles. RIF refers to women who fail to achieve a clinical pregnancy, in a minimum of three embryo transfer cycles with at least four good-quality embryos were transferred in a woman \< 40 years. It affects approximately 10% of ICSI cases. Many management protocols aimed to enhance ICSI outcome in cases of RIF, however, none of them examined the effect of freeze all policy in this category of patients.
Interventions
OTHERFreeze all policy
Cryopreservation of human blastocysts for freeze all group has been employed using vitrification. The blastocysts were transferred after thawing in a frozen-thawed cycle.
Sponsors
TopLab Company for ART Laboratories Consultation and Training
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 39 Years
Healthy volunteers
No
Inclusion criteria
1. gonadotropin-releasing hormone agonist and recombinant follicle-stimulating hormone (FSH) in a long protocol cycles; 2. female partners were under age of 40 years; 3. all the patients had a history of recurrent implantation failure i.e: failed to achieve a clinical pregnancy after at least three fresh ICSI cycles where at least 8 good embryos were transferred; 4. their embryos were pushed to Day 5 resulting in blastocysts, and undergo embryo transfer day 5 or vitrification on day 5; 5. endometrial thickness ≥ 7 mm; 6. selected embryos for embryo transfer were blastocysts. -
Exclusion criteria
Couples with testicular or epididymal sperm were excluded. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | 4 weeks post embryo transfer | Clinical pregnancy was identified by fetal cardiac activity on ultrasound examination 4 weeks after embryo transfer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ongoing pregnancy rate | 10 weeks post embryo transfer | Ongoing pregnancy rate was defined as the number of pregnancies with visible fetal heart motion over the number of transferred embryos at 10 weeks' gestation. |
| Implantation rate | 6 weeks after embryo transfer | Implantation rate was defined as the number of intrauterine gestational sacs over the total number of embryos transferred. |
Outcome results
None listed