Complications; Anesthesia, Spinal and Epidural, in Pregnancy
Conditions
Brief summary
Prevention of postspinal hypotension after spinal anesthesia for caesarian section by use of preoperative or intraoperative volume replacement. The comparison of crystalloid and colloid infusions and their timing via perfusion index and plethysmographic variability index.
Detailed description
To Prevent hypotension fluid replacement is usually used in pregnant patients scheduled for C/S. Different types of fluids can be used in order to achieve this. Also the timing of fluid replacement is important. In the present study patients were separated into 4 groups. Each receiving a one of two fluids in different times. ( Colloid pre-load, colloid co-load, crystalloid co-load and crystalloid pre-load.) The effect of overall hemodynamics and the incidence of hypotension are evaluated. Also peripheric monitors like perfusion index and plethysmographic variability index are evaluated for correlation.
Interventions
OTHERColloid Preload
preload infusion
OTHERcolloid co-load
co-load infusion
OTHERCrystalloid preload
preload infusion
OTHERCrystalloid Co-load
co-load infusion
Sponsors
Balikesir University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
the outcome accessor and care provider will be aware in which gropu the patient was
Intervention model description
4 group of patients were sheduled to receive either kristalloid or kolloid two gropus before and two groups during anesthesia induction
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* pregnant 37-41 weeks * one fetus * scheduled for C/S under spinal anesthesia * accepting to participate
Exclusion criteria
* Emergency surgery * placenta previa * preeclampsia * cardiovascular and cerebrovascular comorbidities * morbid obesity (BMI\>40) * pregnancy weeks \<36 and \> 41 * The use of vasoconstrictors * Severe Anemia ( Hb \<9 g/dl) * Refusal or known contraindication for spinal anesthesia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants in each group who develop hypotension, and correlation between hypotension and Perfusion Index (PI) and Plethysmographic Variability Index (PVI) scores | Measurements will be performed at 5 minute intervals beginning 15 minutes prior to the operation, throughout the whole operation untill the end. | Hypotension is going tobe measured in mmHG in 5 minute intervals and PI and PVI measurements are also recorded at the same time intervals. A decrease in blood presssure exceeding % 20 of the preoperative basal blood pressure measurement will be recorded as hypotension. The number of patients who develop hypotension will be recorded. Statistic difference will be avaluated between groups. Hypotensive episodes are going to be comparised with the PI and PVI measurements at the same time period and evaluation for correlation will be performed. |
Countries
Turkey (Türkiye)
Outcome results
None listed