Cognition Disorders, Memory Deficits, Neurobehavioral Manifestations, Traumatic Brain Injuries
Conditions
Brief summary
The study will be conducted over 18 months. The main objective of this study is to explore the relationships between autobiographical memory and specific cognitive measures, as well as emotional and behavioural measures in patients who have suffered a moderate to severe TBI. Secondary objectives are to assess the psychometric properties of a self-defining memories questionnaire and to characterize autobiographical memory in the TBI population.
Detailed description
A total of 40 participants (20 non-consecutive adults with a moderate or severe TBI and 20 volunteers with any history of neurological or psychiatric disease) will be recruited into the study. The duration of the protocol is 70 minutes. As regards the assessment, three questionnaires will be administered in order to evaluate self-defining memories, apathetic manifestations and anxio-depressive symptoms. In addition, four cognitive measures will be used to assess verbal episodic memory, working memory, cognitive flexibility and verbal fluency.
Interventions
OTHERQuestionnaires and cognitive measures
Sponsors
Centre d'Investigation Clinique et Technologique 805
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* patients with a moderate or severe TBI occurred at least 6 months ago (initial Glasgow Coma Scale score ≤ 12 or post-traumatic amnesia duration \> 1 week) * patients ≥ 18 years old and who have signed a letter of information
Exclusion criteria
* history of neurological and/or psychiatric disease * persistent motor, sensitive and instrumental disorders that could disturb the efficient evaluation of the participant * patients who refused to participate in the study * non affiliation to a social security scheme * patients under guardianship or trusteeship * pregnant woman
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| self-defining memory score | 20 minutes | self-defining memories will be measured using the self-defining memories questionnaire |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| working memory score | 10 minutes | working memory will be measured using verbal span task |
| cognitive flexibility score | 5 minutes | cognitive flexibility will be measured using the Trail Making Test |
| verbal episodic memory score | 20 minutes | verbal episodic memory will be measured using the California Verbal Learning Test |
| apathy score | 5 minutes | apathetic manifestations will be measured using the Apathy Evaluation Scale |
| anxio-depressive score | 5 minutes | anxio-depressive symptoms will be measured using the Hospital Anxiety and Depression Scale |
| verbal fluency score | 5 minutes | verbal fluency will be measured using the verbal fluency task |
Countries
France
Outcome results
None listed