Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft in Periodontal Intrabony Defects

Clinical and Radiographic Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft for Management of Periodontal Intrabony Defects: a Randomized Clinical Trial.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02679209

Enrollment

Registered

2016-02-10

Start date

2015-06-30

Completion date

2017-06-30

Last updated

2018-04-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis

Brief summary

A clinical and radiographic evaluation of 2 regenerative techniques, bioresorbable membrane and bone allograft for management of periodontal intrabony defects.

Detailed description

Twenty-two patients suffering from advanced chronic periodontitis were included in this randomized controlled clinical trial. Each subject contributed had two- or three-walled intrabony defects. Patients were randomly assigned into two groups; bioresorbable membrane or bone allograft. Clinical parameters were recorded at baseline and at 3 and 6 months postoperatively. Radiographic parameters were recorded at baseline and at 6 months postoperatively.

Interventions

BIOLOGICALDemineralized bone matrix in putty form

it is a type of bone graft from human cadavers.

BIOLOGICALAmnion chorion membrane

A bioresorbable allograft membrane for guided tissue regeneration from amnion and chorion parts of the placenta from pregnant females for guided tissue regeneration.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

35 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Severe chronic periodontitis patients. * having at least one site with pocket depth ≥ 6 mm and clinical attachment level ≥ 5 mm, with radiographic evidence of bone loss as detected in periapical radiographs.

Exclusion criteria

* Pregnant women * Having any given systemic disease * Taking any type of medication and/or antibiotic therapy during the 3 months before the study * Received periodontal treatment within the past 12 months Current or former smokers

Design outcomes

Primary

Measure	Time frame	Description
Clinical attachment level	change from Baseline at 6 months	Change from baseline in clinical attachment level in mm in chronic periodontitis patients

Secondary

Measure	Time frame	Description
bone defect area	Baseline and 6 months	Estimation of bone fill defect area in mm square in chronic periodontitis patients at baseline and 6 month
pocket depth	Baseline and 6 months	Estimation of pocket depth in mm in chronic periodontitis patients at baseline and 6 months

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026