Vitamin D Deficiency
Conditions
Keywords
Vitamin D-biofortified eggs, Vitamin D status, RCT
Brief summary
While there have been a considerable number of studies on the impact of additional vitamin D in the diets of hens on the resulting egg vitamin D content, the effect of consumption of such vitamin D-enhanced eggs on vitamin D status of healthy human subjects has not been tested in a RCT.
Detailed description
The aim of this study was to investigate the effect of consumption of vitamin D3 versus 25-hydroxyvitamin D3 biofortified eggs on winter serum 25(OH)D in adults using a 8-wk randomized controlled trial. This research will provide new data on the potential of vitamin D enriched eggs as a food-based strategy for prevention of vitamin D deficiency.
Interventions
DIETARY_SUPPLEMENTControl eggs
Control eggs containing no additional vitamin D beyond norm
DIETARY_SUPPLEMENTVitamin D3 eggs
Vitamin D3-biofortified eggs
DIETARY_SUPPLEMENT25-Hydroxyvitamin D3 eggs
25-Hydroxyvitamin D3-biofortified eggs
Sponsors
University College Cork
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
\- consenting white men and women aged 45-70 years
Exclusion criteria
* consumption of vitamin D-containing supplements throughout the study. planning to take a winter vacation (during the course of the 8-wk intervention) - to a location at which either the altitude or the latitude would be predicted to result in significant cutaneous vitamin D synthesis from solar radiation * planning to use tanning facilities of any type. * a severe medical illness, * allergy to egg products, * medically advised to limit egg intake in relation to managing hypercholesterolemia, * hypercalcaemia, * known intestinal malabsorption syndrome, * excessive alcohol use, * the use of medications known to interfere with vitamin D metabolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response of serum total 25-hydroxyvitamin D concentration over 8 weeks of winter | up to 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Serum parathyroid hormone | 0 weeks and 8 weeks |
Other
| Measure | Time frame |
|---|---|
| Serum total calcium | 0 weeks and 8 weeks |
| Serum total cholesterol | 0 weeks and 8 weeks |
Countries
Ireland
Outcome results
None listed