Cancer
Conditions
Keywords
cancer, diagnosis, biopsy, chemotherapy drugs, tumor
Brief summary
Characterization of Cancer Tissue Using 3D Biosynthetic Materials. Using liver biopsy from stage 4 cancer patients, the investigators will evaluate and characterize the metastatic cells.
Detailed description
The investigators' biomaterial lab has developed an in vitro diagnostic system in which a cancer tumor is placed inside a 3D hydrogel. This material has similar properties to the human tissue and can visualize cell migration and proliferation. In this system, the investigators have already characterised human metastatic cells obtained from nude mice tumors. The diagnostic assay is able to evaluate the reduction in cell growth associated with anti-cancer drug therapy. The next step is to test the in vitro diagnostic system using human tissue samples from human patients, and to validate the system as a simple and effective a priori diagnostic tool for characterizing patient tumours.
Interventions
PROCEDUREAnalyzing biopsy samples
Analyzing biopsy samples that is preformed as part of the patient treatment.
Sponsors
Rambam Health Care Campus
Technion, Israel Institute of Technology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* liver tumor
Exclusion criteria
* refuse to volunteer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cell growth | 1 week | biopsy will be placed inside 3D gel, and growth will be measured over 1 week time. |
Countries
Israel
Contacts
Primary Contacttarek Saadi, Dr.
Backup Contactshlomit harpaz, Msc
Outcome results
None listed