Acute Stroke
Conditions
Keywords
Ischemic Stroke, Anesthesia, Endovascular Procedures
Brief summary
Recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment. It is unknown whether there is a causal relationship in this observation. The investigators are performing a large randomised trial of general versus local anaesthesia to definitively answer the question of whether anaesthetic type alters perioperative outcome.
Interventions
OTHERlocal anesthesia
Sponsors
Beijing Tiantan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with AIS scheduled to receive emergency endovascular treatment, older than 18; the onset time is within 12 hours.
Exclusion criteria
* Radiological ambiguity concerning infarction and vessel occlusion. * Additional intracerebral hemorrhage. * Posterior circulation infraction. * Coma on admission (Glasgow coma score less than 8). * NIHSS less than 10 or more than 35. * Severe agitation or seizures on admission. * Obvious loss of airway protective reflexes and/or vomiting on admission. * Being intubated before treatment on admission. * Known allergy to anesthetic or analgesic.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| modified Rankin score | post-procedural 30 days |
Countries
China
Contacts
Primary ContactRuquan Han, M.D., Ph.D.
Outcome results
None listed