Polycystic Ovary Syndrome
Conditions
Keywords
polycystic ovary syndrome, Serum anti-Mullerian hormone, glucose intolerance, metabolic syndrome
Brief summary
Association between serum anti-Mullerian hormone (AMH) level and prevalence of glucose intolerance and metabolic syndrome in women with polycystic ovary syndrome (PCOS)
Detailed description
* To study the association between serum anti-Mullerian hormone (AMH) level and glucose intolerance and metabolic syndrome in women with polycystic ovary syndrome (PCOS). * Glucose intolerance is detected by 2-hours 75 gram oral glucose tolerance test (OGTT). * Metabolic syndrome is diagnosed by using the Harmonized criteria; the presence of any 3 of 5 following risk factors constitutes a diagnosis of metabolic syndrome. 1. Elevated waist circumference (\> 80 cm in Asian women) 2. Elevated triglycerides (\> 150 mg/dL) 3. Reduced HDL-cholesterol (\< 50 mg/dL) 4. Elevated blood pressure )systolic \> 130 and/or diastolic \> 85 mmHg) 5. Elevated fasting glucose ( \> 100 mg/dL) * Percentage of glucose intolerance and metabolic syndrome in PCOS women as well was any differences in parameters between PCOS patients with and without glucose intolerance and metabolic syndrome will be analysed.
Interventions
OTHERserum
Serum for serum anti-Mullerian hormone, 2-hour 75 gram oral glucose tolerance test and lipid profiles
Sponsors
Chulalongkorn University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* PCOS diagnosed by Rotterdam criteria 2003
Exclusion criteria
* Pregnancy * Previous any hormonal uses in the last 3 months * Previous hypoglycemic drugs or insulin-sensitising agents use in the last 3 months * Previous chemotherapy, ovarian surgery, pelvic irradiation * Menopause
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences between serum AMH level between PCOS women with and without glucose intolerance and metabolic syndrome | 6 months | Any differences between mean of serum AMH levels in PCOS with and without glucose intolerance and metabolic syndrome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of glucose intolerance in PCOS women | 6 months | Percentage of glucose intolerance detected by 75 g OGTT in PCOS women |
| Percentage of metabolic syndrome in PCOS women | 6 months | Percentage of metabolic syndrome defined by the Harmonized criteria in PCOS women |
Countries
Thailand
Contacts
Primary ContactWasamon Tunsuparp, MD
Backup ContactPorntip Sirayapiwat, MD, MSc
Outcome results
None listed