Brad Arrhythmia Induced by Repeated Succinylcholine During Gynecological Laparoscopic Surgery

Prevention of Brad Arrhythmia Induced by Repeated Succinylcholine by Atropine Sulfate During Gynecological Laparoscopic Surgery: a Randomized Controlled Trial

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02676011

Enrollment

120

Registered

2016-02-05

Start date

2016-02-29

Completion date

2016-05-31

Last updated

2016-09-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bradycardia

Keywords

Atropine, Succinycholine, Laparoscopy, Gynecology

Brief summary

Cardiac arrhythmias are a well-recognized complication of anesthesia for laparoscopy. The aim of this study was to evaluate the efficacy of atropine sulfate for prevention of brad arrhythmia induced by repeated succinylcholine during gynecological laparoscopic surgery.

Detailed description

120 candidates, ASA 1 in the age range 18-40 years scheduled for elective diagnostic gynecological laparoscopic surgery were randomly assigned into 4 groups to receive either atropine sulfate or normal saline solution (as placebo).

Interventions

DRUGIM atropine

Atropine (0.01 mg/kg) (1 ml) IM 30 minutes before induction of anesthesia

DRUGIV atropine

Atropine (0.01 mg/kg) intravenously (10 ml) 3 minutes before induction of anesthesia

DRUGAtropine mixed with second dose succinylcholine

Atropine (0.01 mg/kg) added to the second dose succinylcholine (1mg/kg) prepared to 5 ml syringe with normal saline

DRUGIM normal saline

1 ml normal saline IM 30 minutes before induction of anesthesia

DRUGIV normal saline

IV 10 ml normal saline 3 minutes before induction of anesthesia

DRUGNormal saline mixed with second dose succinylcholine

Second dose succinylcholine (1 mg/kg) prepared to 5 ml syringe with normal saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Female patients 18-50 years scheduled for elective diagnostic gynecological laparoscopic surgery

Exclusion criteria

* Cardiac * Diabetes Mellitus * Thyroid disease * Any endocrine disease

Design outcomes

Primary

Measure	Time frame	Description
Occurrence of bradycardia	within the first 2 hours during surgery	heart rate less than 60 per minutes or decrease more than 30% of baseline reading

Secondary

Measure	Time frame	Description
Nasopharyngeal secretion	within the first 4 hours during surgery	suction of Nasopharyngeal secretion (ml) during and after extubation

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026