Healthy
Conditions
Keywords
guar gum, konjac mannan, blood glucose, legume flour
Brief summary
Identify one or more flat bread mixes that produce a reduction in positive incremental area under the curve (iAUC) of post-prandial glucose relative to the control product.
Detailed description
This study was a double-blind, randomised, balanced incomplete block design exploratory study of efficacy, with 11 active treatments compared to a control product in 42 healthy subjects to see if a mix of active ingredients (viscous fibres and flours) lowered the post-prandial glucose (PPG) response in capillary blood (finger prick) over a two and three hours period, relative to the control product. Every subject received the control and 4 out of the 11 treatments on five separate test days.
Interventions
OTHERControl
100 g high fibre flour
OTHERActive 2
98 g high fibre flour + 2 g guar gum
OTHERActive 3
88 g high fibre flour + 2 g guar gum + 10 g legume flour
OTHERActive 4
83 g high fibre flour + 2 g guar gum + 15 g legume flour
OTHERActive 5
96 g high fibre flour + 4 g guar gum
OTHERActive 6
86 g high fibre flour + 4 g guar gum + 10 g legume flour
OTHERActive 7
81 g high fibre flour + 4 g guar gum + 15 g legume flour
OTHERActive 8
94 g high fibre flour + 6 g guar gum
OTHERActive 9
98 g high fibre flour + 2 g konjac mannan
OTHERActive 10
96 g high fibre flour + 4 g konjac mannan
OTHERActive 11
100 g low fibre flour
OTHERActive 1
85 g high fibre flour + 15 g legume flour
Sponsors
Unilever R&D
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index (BMI) ≥ 20 and ≤ 25.0 kg/m2. * Apparently healthy: no medical conditions which might affect study measurements (as judged by the study physician). * A fasting blood glucose value between 3.5 - 5.6 mmol/litre at screening (measured by finger prick).
Exclusion criteria
* Use of medication which interferes with study measurements (as judged by the study physician). * Reported dietary habits: medically prescribed diet, slimming diet, not used to eat 3 meals a day, vegetarian. * Reported weight loss/gain (\>10%) in the last six month before the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive incremental area under the curve (iAUC) | 120 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Positive incremental area under the curve (iAUC) | 180 minutes |
Countries
United Kingdom
Outcome results
None listed