Anastomotic Leak
Conditions
Keywords
ICG, colectomy, anastomotic leak, anastomotic leakage rate, surgical decision
Brief summary
The aim of this study was to evaluate the impact of fluorescence imaging on the location of colorectal transection lines based on evaluation of perfusion with indocyanine green, how it's going to affect surgical planning and its possible benefits in reducing anastomotic leakage.
Detailed description
During surgery, the line of intended bowel transection would be determined by the surgeon. Then the anesthesiologist will administer a bolus of 5mg ICG intravenously (2.5mg/ml, 2ml), followed by 10ml normal saline flush. The perfusion of colon will be assessed via fluorescence angiography. The actual bowel transection, after ICG fluorescence study, would be compared with the intended bowel transection site. The difference in terms of distance and either more proximal or distal is recorded. Then bowel anastomosis is completed in the usual manner.
Interventions
DRUGindocyanine green
Injection of indocyanine green and using fluorescence imaging to assess perfusion of bowel before bowel transection and anastomosis
DEVICEFluorescence imaging
Sponsors
The University of Hong Kong
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* All left-sided colorectal resection involving division of inferior mesenteric artery
Exclusion criteria
* Patients with a history of adverse reaction or known allergy to ICG, iodine, or iodine dyes. Pregnant and/or lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients with operative decisions changed after the use of ICG enhanced fluorescence imaging | intraoperative |
Secondary
| Measure | Time frame |
|---|---|
| Anastomotic leak | up to 2 weeks after operation |
Countries
Hong Kong
Contacts
Primary ContactDominic, Chi Chung Foo, MBBS
Outcome results
None listed