Misoprostol for Second Trimester Pregnancy Termination

Intra Uterine Extra Amniotic (200 μg ) Versus Vaginal (200 μg) Misoprostol for Second Trimester Pregnancy Termination: Randomized Controlled Trial

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02669420

Acronym

MIS

Enrollment

180

Registered

2016-02-01

Start date

2015-01-31

Completion date

2016-01-31

Last updated

2016-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intra Uterine Fetal Death

Brief summary

The majority of second-trimester pregnancy termination performed in the United States are performed surgically by dilation and evacuation. The frequency of induction of abortion increases as gestational age advances. In the late second trimester and early third trimester, induction is the primary method of termination in cases of fetal abnormalities. In many other countries, however, induction is the primary method of abortion throughout the second trimester

Interventions

PROCEDUREtermination of second trimester pregnancy

Intra uterine extra amniotic (200 μg ) versus Vaginal (200 μg) Misoprostol for Second Trimester Pregnancy Termination. Randomized controlled trial

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* Pregnancy 13-24 weeks. * Women with indication for termination of the pregnancy due to intra uterine fetal death

Exclusion criteria

-Pregnancy before 13 weeks. * Pregnancy beyond 24 weeks. * Women with scared uterus. * Known hypersensitivity for misoprostol. * Refusal of the woman to participate.

Design outcomes

Primary

Measure	Time frame
mean duration from the initial misoprostol dose until complete fetal expulsion	24 hours

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026