Magnesium Sulfate Effects on Onset and Duration of Low Dose Rocuronium in Patients Undergoing Laparoscopic Cholecystectomy

Effects of Magnesium Sulfate on Onset and Duration of Low Dose Rocuronium in Patients Undergoing Laparoscopic Cholecystectomy

Status

UNKNOWN

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02669368

Enrollment

Registered

2016-02-01

Start date

2015-03-31

Completion date

Unknown

Last updated

2016-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Relaxation

Brief summary

This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition in patients undergoing laparoscopic cholecystectomy.

Interventions

DRUGMagnesium Sulfate

Patients in each group receive Magnesium sulfate 30 mg/kg in 0.9% normal saline (total volume 100 ml) intravenously for 5 min before induction of anesthesia

DRUGSaline

Patients in each group receive 0.9% normal saline (total volume 100 ml) alone intravenously for 5 min before induction of anesthesia

DRUGStandard dose Rocuronium

0.6 mg/kg of Rocuronium given with induction of anesthesia

DRUGLow dose Rocuronium

0.45 mg/kg of Rocuronium given with induction of anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* American Society of Anesthesiologists physical status 1 or 2. * BMI of 25-34.9 kg/m2. * Patients scheduled for laparoscopic cholecystectomy.

Exclusion criteria

* Severe respiratory or cardiac disease. * Hepatic or renal function impairment. * Neuromuscular disease. * Patients on medications affecting neuromuscular function. * Patients with known allergy to the drugs.

Design outcomes

Primary

Measure	Time frame	Description
The time of onset the action of Rocuronium	Time from injection of Rocuronium till T1 suppression more than 95% up to 10 minutes.	by using the TOF watch nerve stimulator
The time at which Maximal suppression	Time from the injection of Rocuronium to T1 maximal suppression time (TOF=0) up to an hour.	by using the TOF watch nerve stimulator
Reversal of Rocuronium	Time from injection of Rocuronium till reversal of T1 (TOF=25%) around an hour after induction of anesthesia	by using the TOF watch nerve stimulator

Secondary

Measure	Time frame	Description
Intubation condition	Within 10 minutes after induction of anesthesia	to score intubation condition on the basis of 6 items: Jaw relaxation, laryngoscopy, vocal cord position, moving of limbs, coughing & change in heart rate.
Surgical condition	During surgery	to score a surgical condition according to 7 point likert scale

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026