The Effects of Intrauterine Infusion of hCG at the Time of Embryo Transfer

The Effects of Intrauterine Infusion of Human Chorionic Gonadotropin at the Time of Embryo Transfer on IVF/ICSI Outcomes: Randomized, Double-blind Controlled Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02668965

Enrollment

200

Registered

2016-01-29

Start date

2015-12-31

Completion date

2016-04-30

Last updated

2016-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

Clinical pregnancy rate

Brief summary

The purpose of this study is to determine whether intrauterine hCG can improve the implantation rate and clinical pregnancy rate after embryo transfer in IVF/ICSI cycle.

Detailed description

Patients at infertility clinic, siriraj hospital who come to start IVF/ICSI treatment cycle or endometrial preparation for embryo transfer are consiferes as eligible subjects. On the day of embryo transfer (both fresh and frozen-thaw cycle), the subjects will be randomized to 2 groups. 1. control group: embryo transfer after intrauterine infusion with standard embryo culture media 4-7 minutes 2. study group: embryo transfer after intrauterine infusion with hCG (Pregnyl) 4-7 minutes The patients will come back for serum beta-hCG measurement 2 weeks later after embryo transfer and other 2 weeks later for transvaginal ultrasound if beta-hCG is positive.

Interventions

PROCEDUREIntrauterine hCG (pregnyl)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 43 Years

Healthy volunteers

Yes

Inclusion criteria

1. infertile women aged 18-43 years 2. indicated or willing for IVF/ICSI treatment or endometrial preparation for embryo transfer

Exclusion criteria

1. Azoospermic male partner 2. Failure to retrieve oocyte after controlled ovarian hyperstimulation 3. No embryo retrieved for transfer 4. Endometrial preparation failure

Design outcomes

Primary

Measure	Time frame	Description
Clinical pregnancy rate	2 weeks after positive serum beta-hCG	Transvaginal ultrasound to confirm number of intrauterine gestational sac and fetal heart beats

Secondary

Measure	Time frame	Description
Chemical pregnancy rate	2 weeks after embryo transfer	positive serum beta-hCG more than 3
Implantation rate	2 weeks after positive serum beta-hCG	number of intrauterine gestational sac / number of embryo transferred

Countries

Thailand

Contacts

Primary Contactsavinee boonsuk, M.D.

noomnim_mu@hotmail.com+66818706643

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026