Comparison of Pre-oxygenation of NIV and HFNC Therapy for Intubation of ICU Patients With Acute Respiratory Failure

Conditions

Acute Respiratory Failure, Intratracheal Intubation

Brief summary

The aim of the study is to evaluate the incidence of severe hypoxemia episodes during the intubation procedure with two methods of pre-oxygenation: 1. NIV (Non Invasive Ventilation) 2. HFNC (High-flow nasal canula oxygen therapy)

Detailed description

Design: Clinical randomized, open, multicenter, comparative trial, with parallel groups aimed at evaluating a medical device. Selection of patients admitted to the ICU for acute respiratory failure, requiring endotracheal intubation. Randomized study, inclusion in two groups: NIV or HFNC. Experimental group: NHFC group, preoxygenation by NHFC: oxygen flow rate of 60 L / min and 100% FiO2. Control group: NIV group, preoxygenation by NIV: pressure support set for an exhaled tidal volume of 6-8 ml / kg of ideal body weight, PEEP of 5 cm H2O and FiO2 at 100%. Duration of participation of each patient: 28 days

Maeva Rodriguez, Stéphanie Ragot, Rémi Coudroy, Jean‐Pierre Quenot, Philippe Vignon et al. (62 authors)

Annals of Intensive Care2021-07-2211 citations

10.1186/s13613-021-00892-8

Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial.

Frat JP, Ricard JD, Quenot JP, Pichon N, Demoule A, Forel JM, Mira JP, Coudroy R, Berquier G, Voisin B, Colin G, Pons B, Danin PE, Devaquet J, Prat G, Clere-Jehl R, Petitpas F, Vivier E, Razazi K, Nay MA, Souday V, Dellamonica J, Argaud L, Ehrmann S, Gibelin A, Girault C, Andreu P, Vignon P, Dangers L, Ragot S, Thille AW, FLORALI-2 study group, REVA network.

2019-03-18116 citations

10.1016/s2213-2600(19)30048-7

Preoxygenation with non-invasive ventilation versus high-flow nasal cannula oxygen therapy for intubation of patients with acute hypoxaemic respiratory failure in ICU: the prospective randomised controlled FLORALI-2 study protocol

Jean‐Pierre Frat, Jean-Damien Ricard, Rémi Coudroy, René Robert, Stéphanie Ragot et al. (6 authors)

BMJ Open2017-12-0122 citations

10.1136/bmjopen-2017-018611

Interventions

PROCEDUREHigh Flow nasal canula oxygen therapy

Pre-oxygenation with high-flow nasal canula oxygen therapy

PROCEDURENoninvasive ventilation

Pre-oxygenation with non-invasive ventilation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

Main inclusion Criteria: * acute hypoxemic respiratory failure requiring endotracheal intubation Main

Exclusion criteria

* coma * NIV contraindication

Design outcomes

Primary

Measure	Time frame	Description
Severe desaturation as defined by a pulse oxymetry below 80%	through five minutes after preoxygenation period	drop below 80% of pulse oxymetry measurement

Countries

France

Outcome results

None listed