Pain
Conditions
Keywords
propofol, lidocaine, pregabalin
Brief summary
Pain is a common side effect of propofol injection. The purpose of this study was to compare the efficacy of pregabalin and lidocaine in reducing propofol injection pain.
Detailed description
In a randomized, double blind, prospective trial, 120 patients were allocated to one of three groups (each n=40) receiving intravenous lidocaine 40mg (group L), oral pregabalin 75 mg (group LP), and oral pregabalin 150 mg (group HP) as pretreatment, followed by injection of 25% of 2 mg/kg propofol. Pain was assessed by a four point scale (0=no, 1=mild, 2=moderate, 3=severe pain).
Interventions
DRUGLidocaine
DRUGPregabalin
DRUGpropofol
Sponsors
Kyungpook National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patient underwent elective dental surgery.
Exclusion criteria
* Patient with a history of adverse response to lidocaine or pregabalin, * Patient with cardiovascular or respiratory disease, * Patient who takes any sedatives, analgesics, or anticonvulsants within 24 hours before surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Propofol injection pain | 10 seconds after injection of propofol | Thirty seconds after pretreatment, 25% of the total calculated dose of propofol (2 mg/kg) was administrated into a dorsal hand vein. Ten seconds after injection of propofol, pain was assessed on a four-point scale (0=none, 1 = mild, 2= moderate, 3= severe). |
Countries
South Korea
Outcome results
None listed