Physical Activity
Conditions
Brief summary
FGF-21 and insulin are key hormones in the regulation of glucose metabolism. Furthermore, both hormones are influenced by physical activity. The following hypothesis will be tested: FGF-21 is regulated insulin-dependent during exercise.
Detailed description
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by rising global importance. In Germany alone, more than seven million people are being treated currently. T2DM is characterized by permanently elevated blood glucose levels, based on insulin resistance and followed by associated beta cell failure. In our previous work the investigators could already shown that increased FGF-21 levels are accompanied by an increased risk of T2DM. Physical activity is essential in the treatment and the prevention of T2DM. Interestingly, it was shown that acute physical exercise was leading to decreased insulin levels and increased FGF-21 values. In this study the effects of acute physical activity on FGF-21 values should be investigated in 3 groups: a) Healthy volunteers b) persons with T2DM c) persons with T1DM.
Interventions
OTHERspiroergometry
Spiroergometry on a bicycle ergometer
Sponsors
Charite University, Berlin, Germany
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers,persons with T2DM, persons with T1DM
Exclusion criteria
* Patients with contraindications to an exercise ECG or spirometry be excluded from participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FGF-21 change after physical activity | FGF-21 before and 1 h after spiroergometry |
Countries
Germany
Contacts
Primary ContactThomas Bobbert, Dr.
Outcome results
None listed