The Curative Effect of the Length of the Jejunum Exclusion in Grstric Bypass Surgery for Type 2 Diabetes

The Curative Effect of the Length of the Jejunum Exclusion in Grstric Bypass Surgery for Type 2 Diabetes:a Randomized Controlled Trials

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02667652

Enrollment

Registered

2016-01-29

Start date

2016-01-31

Completion date

2020-08-31

Last updated

2022-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, Type 2 Diabetes

Keywords

T2DM, RYGB, RCT

Brief summary

The purpose of this study is to investigate the curative effect of the length of the jejunum exclusion in gastric surgry for T2DM and metabolic syndrome,and to draft Scientific and reasonable operation parameters.

Detailed description

Currently, there is a growing evidence supports the efficacy of Roux-en-Y gastric bypass for the treatment of Type 2 diabetes mellitus. However,there still have a great controversy about the operation parameters. With randomized controlled trial, Patients of BMI\>21kg/m2 with type 2 diabetes were randomly divided into two groups: short biliarypancreatic limb:50cm;long biliarypancreatic limb :100cm. The investigators followed-up 3,6,12,24 months of the change of BMI,FBG,HbA1c,Blood pressure,Blood fat after surgery.

Interventions

PROCEDUREshort biliarypancreatic limb

biliarypancreatic limb:50cm;roux limb:150cm.

PROCEDURElong biliarypancreatic limb

biliarypancreatic limb:100cm;roux limb:100cm.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Aged 20-65 years old * History of diabetes is less than 15 years * Fasting c-peptide≥1.6 * BMI≥21kg/m2； * Ability to understand the nature of the procedure and willing to follow postoperative routine lifestyle and checkups

Exclusion criteria

* Psychological and mental disorders * Serious important organs such as heart and lung disease cannot be tolerated surgery * Complex history of abdominal surgery in the abdominal cavity adhesion * Pregnancy or lactation

Design outcomes

Primary

Measure	Time frame	Description
body mass idex	24 months	Changesd of BMI

Secondary

Measure	Time frame	Description
IFG	24 months	Variations of IFG
HbA1c	24 months	The changes of HbA1c
blood pressure	24 months	Changes of blood pressure including both systolic and diastolic pressure.
blood fat	24 months	Changes of blood fat including LDL, HDL, CHOL, TG

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026